Evidence map›Paper›PMID 28273893›Full record

ArticleScientific reports2017

Dengue virus infection increases microglial cell migration.

Ming-Kai Jhan, Tsung-Ting Tsai, Chia-Ling Chen, Cheng-Chieh Tsai, Yi-Lin Cheng, Yi-Chao Lee, Chiung-Yuan Ko, Yee-Shin Lin, Chih-Peng Chang, Liang-Tzung Lin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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  10. The Causes and Long-Term Consequences of Viral Encephalitis.Frontiers in cellular neuroscience · 2021
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Endothelins in inflammatory neurological diseases.Pharmacology & therapeutics · 2019
    Review
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ming-Kai JhanGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Tsung-Ting TsaiDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Chia-Ling ChenTranslational Research Center, Taipei Medical University, Taipei, 110, Taiwan.
Cheng-Chieh TsaiDepartment of Nursing, Chung Hwa University of Medical Technology, Tainan, 717, Taiwan.
Yi-Lin ChengInstitute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.
Yi-Chao LeeThe Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.ORCID 0000-0003-3451-183X
Chiung-Yuan KoThe Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan.
Yee-Shin LinInstitute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.
Chih-Peng ChangInstitute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.
Liang-Tzung LinGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Chiou-Feng LinGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. cflin2014@tmu.edu.tw.
Taipei Medical University · TWNational Cheng Kung University · TWChung Hwa University of Medical Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activated microglial cells are present in dengue virus (DENV)-infected brains; however, the possible effects of DENV on microglia remain unclear. Here, we demonstrated DENV caused infection, including viral entry, RNA replication, viral protein expression, and virus release, in the murine microglial cell line BV2. DENV infection caused an increase in the formation of the multipolar phenotype in vitro and in vivo without affecting cell growth and cytotoxicity. DENV infection considerably increased cell motility and disrupting either actin filaments or clathrin retarded such effect. Increase in cell migration was only occurred by DENV infection following a clathrin-regulated endocytosis of DENV entry. Ultraviolet-inactivated DENV did not affect cell migration, and pharmacologically blocking toll-like receptor (TLR) 3 and TLR3-related signaling pathways reduced the DENV-induced increase in cell migration. These results demonstrate an advanced effect of DENV infection on microglial migration via a mechanism involving viral entry, RNA release, and TLR3 signal activation.

Indexed as

Actin CytoskeletonAnimalsCell LineCell MovementClathrinDengueDengue VirusEndocytosisHumansMiceMicrogliaModels, BiologicalRNA, ViralSignal TransductionToll-Like Receptor 3Virus InternalizationClathrinRNA, ViralTLR3 protein, mouseToll-Like Receptor 3

Identifiers

PMID28273893
PMCPMC5427823
OpenAlexW2593923358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.