ArticleInternational journal of molecular sciences2017
Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- A Systematic Review of Oropharyngeal Dysphagia Models in Rodents.International journal of environmental research and public health · 2021Pooled it
- Trial
- Research advances in dysphagia animal models.Animal models and experimental medicine · 2025Review
- Chronic Administration with FAD012 (3,5-Dimethyl-4-hydroxycinnamic Acid) Maintains Cerebral Blood Flow and Ameliorates Swallowing Dysfunction After Chronic Cerebral Hypoperfusion in Rats.International journal of molecular sciences · 2025Article
- Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats.International journal of molecular sciences · 2023Article
- Pharmacological and Chemical Potential ofPlants (Basel, Switzerland) · 2022Review
- Wild ItalianFoods (Basel, Switzerland) · 2019Article
- Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies.Nutrients · 2019Review
- Anti-hypertensive Effect of Cereal Antioxidant Ferulic Acid and Its Mechanism of Action.Frontiers in nutrition · 2019Review
- The Chinese herbal formulaNeuropsychiatric disease and treatment · 2018Article
- Phytochemical Analysis of Anti-Inflammatory and Antioxidant Effects ofOxidative medicine and cellular longevity · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bilateral common carotid arteries (2VO) in rats. In 2VO rats, topical administration of water or citric acid to the pharyngolaryngeal region evoked a diminished number of swallowing events with prolonged latency compared to sham-operated control rats. 2VO rats had an increased level of superoxide anion radical, and decreased dopamine and tyrosine hydroxylase enzyme levels in the striatum, suggesting that 2VO augmented cerebral oxidative stress and impaired the striatal dopaminergic system. Furthermore, substance P (SP) expression in the laryngopharyngeal mucosa, which is believed to be positively regulated by dopaminergic signaling in the basal ganglia, was decreased in 2VO rats. Oral treatment with FA (30 mg/kg) for 3 weeks (from one week before 2VO to two weeks after) improved the swallowing reflex and maintained levels of striatal dopamine and laryngopharyngeal SP expression in 2VO rats. These results suggest that FA maintains the swallowing reflex by protecting the dopamine-SP system against ischemia-induced oxidative damage in 2VO rats.
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