Evidence map›Paper›PMID 28273808›Full record

ArticleInternational journal of molecular sciences2017

Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells.

Annapina Russo, Assunta Saide, Silvia Smaldone, Raffaella Faraonio, Giulia Russo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 54 citations in OpenAlex.

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  12. Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins.International journal of molecular sciences · 2021
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  17. PheophorbideMarine drugs · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Annapina RussoDepartment of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy. annapina.russo@unina.it.
Assunta SaideDepartment of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy. assuntasaide@gmail.com.
Silvia SmaldoneDepartment of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. silvia.smaldone@gmail.com.
Raffaella FaraonioDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy. raffaella.faraonio@unina.it.
Giulia RussoDepartment of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy. giulia.russo@unina.it.
University of Naples Federico II · ITIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is one of the most common causes of death among adults. Chemotherapy is crucial in determining patient survival and quality of life. However, the development of multidrug resistance (MDR) continues to pose a significant challenge in the management of cancer. In this study, we analyzed the role of human ribosomal protein uL3 (formerly rpL3) in multidrug resistance. Our studies revealed that uL3 is a key determinant of multidrug resistance in

Indexed as

Drug Resistance, MultipleDrug Resistance, NeoplasmMutationAmino Acid Transport System y+Antineoplastic AgentsCell Line, TumorCells, CulturedGene Expression Regulation, NeoplasticGlutathione TransferaseHumansIsoenzymesLung NeoplasmsModels, BiologicalOxidative StressReactive Oxygen SpeciesRepressor ProteinsAmino Acid Transport System y+Antineoplastic Agentsglutathione S-transferase alphaGlutathione TransferaseIsoenzymesReactive Oxygen SpeciesRepressor ProteinsRibosomal Protein L3Ribosomal ProteinsRPL3 protein, humanSLC7A11 protein, humanTumor Suppressor Protein p53chemoresistanceGST-α1lung cancerMDR1multidrug resistanceNrf2nucleolar stressribosomal proteinuL3xCT

Identifiers

PMID28273808
PMCPMC5372563
OpenAlexW2594655436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.