Evidence map›Paper›PMID 28273786›Full record

ArticleInternational journal of cardiology2017

Influence of statin therapy at time of stroke onset on functional outcome among patients with atrial fibrillation.

Darae Ko, Jonathan L Thigpen, James A Otis, Kristen Forster, Lori Henault, Emily Quinn, Yorghos Tripodis, Peter B Berger, Nita Limdi, Elaine M Hylek

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Darae KoDepartment of Medicine, Boston University School of Medicine, Boston, MA, United States. Electronic address: daraeko@bu.edu.
Jonathan L ThigpenDepartment of Clinical and Administrative Sciences, Notre Dame of Maryland School of Pharmacy, Baltimore, MD, United States.
James A OtisDepartment of Neurology, Boston University School of Medicine, Boston, MA, United States.
Kristen ForsterDepartment of Cardiology, Geisinger Health System, Danville, PA, United States.
Lori HenaultDepartment of Medicine, Boston University School of Medicine, Boston, MA, United States.
Emily QuinnDepartment of Biostatistics, Boston University School Public Health, Boston, MA, United States.
Yorghos TripodisDepartment of Biostatistics, Boston University School Public Health, Boston, MA, United States.
Peter B BergerDepartment of Cardiology, Geisinger Health System, Danville, PA, United States.
Nita LimdiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
Elaine M HylekDepartment of Medicine, Boston University School of Medicine, Boston, MA, United States.

Funding

Multidisciplinary Training in Cardiovascular ResearchT32HL007224 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM, WAINFORD, RICHARD DAVID · 1985 to 2020
$12.3M
Boston University Clinical and Translational Science Institute - U ProgramU54TR001012 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2014 to 2014
$3.9M
Effect of Statins and Modifiable Factors on Stroke Outcome in Atrial FibrillationR01NS070307 · NINDS · BOSTON MEDICAL CENTER · PI HYLEK, ELAINE · 2010 to 2012
$1.6M
NCATS NIH HHS U54 TR001012NHLBI NIH HHS T32 HL007224NINDS NIH HHS R01 NS070307
6 · The paper itself

Abstract

backgroundStatin pretreatment has been associated with reduced infarct volume in nonlacunar strokes. The effect of statins on functional outcomes of strokes related to atrial fibrillation (AF) is unknown. We aimed to define the influence of prestroke statin use on functional outcome in AF.

methodsWe assembled a cohort of consecutive ischemic stroke patients from 2006 to 2010. All patients underwent CT or MRI and were adjudicated by site investigators. AF was confirmed by electrocardiogram in 100% of patients. Site neurologists blinded to the study hypothesis affirmed the type of stroke and assessed the severity of disability at the time of hospital discharge. The frequency of death at 30-days was calculated.

resultsIschemic stroke (n=1030) resulted in a severe neurological deficit or death (modified Rankin scale ≥4) at 30days in 711 patients (69%). Using multivariable logistic regression models adjusting for factors associated with statin treatment and factors associated with functional outcome, prestroke statin use was associated with a 32% reduction in frequency of severe stroke (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.50-0.92; P=0.011). Other independent factors associated with severe stroke included older age, female sex, non-White race, diabetes mellitus, prior ischemic stroke, prior venous thromboembolism, and dementia.

conclusionIschemic strokes in AF are associated with high mortality and morbidity. Statin use at time of stroke onset among patients with AF was associated in this study with less severe stroke and warrant validation.

Indexed as

AgedAged, 80 and overAtrial FibrillationBrain IschemiaFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLogistic ModelsMaleStrokeSurvival AnalysisTreatment OutcomeHydroxymethylglutaryl-CoA Reductase InhibitorsAtrial fibrillationHydroxymethylglutaryl-CoA reductase inhibitorsRisk factorsStrokeTherapy

Identifiers

PMID28273786
PMCPMC5347145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.