Evidence map›Paper›PMID 28273525›Full record

ReviewCurrent opinion in neurobiology2017

Multisensory integration in C. elegans.

D Dipon Ghosh, Michael N Nitabach, Yun Zhang, Gareth Harris

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. From small brains to smart machines: translatingFrontiers in neural circuits · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Sensory integration of food and population density during the diapause exit decision involves insulin-like signaling inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Review
  11. FUNCTIONS OFbioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Semantic Representation of Neural Circuit Knowledge inbioRxiv : the preprint server for biology · 2023
    Article
  17. Multisensory Integration inBrain sciences · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

D Dipon GhoshDepartment of Cellular and Molecular Physiology, Yale University, New Haven, CT, United States.
Michael N NitabachDepartment of Cellular and Molecular Physiology, Yale University, New Haven, CT, United States; Department of Genetics, Yale University, New Haven, CT, United States; Kavli Institute for Neuroscience, Yale University, New Haven, CT, United States. Electronic address: michael.nitabach@yale.edu.
Yun ZhangDepartment of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA, United States. Electronic address: yzhang@oeb.harvard.edu.
Gareth HarrisDepartment of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA, United States.

Funding

PROJECT 4: MOLECULAR AND CELLULAR MECHANISMS FOR THERMAL ROBUSTNESS AND MULTISENP01GM103770 · NIGMS · BRANDEIS UNIVERSITY · PI SAMUEL, ARAVINTHAN D. · 2013 to 2017
$6.2M
Synaptic Microcircuits Underlying Associative LearningR01NS091070 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2014 to 2024
$4.0M
Molecular and Cellular Mechanisms of a Neuronal Network that Regulates OlfactoryR01DC009852 · NIDCD · HARVARD UNIVERSITY · PI ZHANG, YUN · 2009 to 2017
$3.5M
Transgenic Tethered Spider ToxinsR01NS056443 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2006 to 2014
$3.4M
Peptide Modulation of Physiology and BehaviorR01GM098931 · NIGMS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2011 to 2019
$3.0M
Functional characterization of an insulin-like peptide network that regulates learningR01GM108962 · NIGMS · HARVARD UNIVERSITY · PI ZHANG, YUN · 2014 to 2017
$2.2M
Neuropeptide modulation of C. elegans light avoidance circuitryF31NS080628 · NINDS · YALE UNIVERSITY · PI GHOSH, DEBTIRTHO DIPON · 2013 to 2015
$72k
NIDCD NIH HHS R01 DC009852NIGMS NIH HHS P01 GM103770NIGMS NIH HHS R01 GM098931NIGMS NIH HHS R01 GM108962NINDS NIH HHS F31 NS080628NINDS NIH HHS R01 NS056443NINDS NIH HHS R01 NS091070
6 · The paper itself

Abstract

Multisensory integration is a neural process by which signals from two or more distinct sensory channels are simultaneously processed to form a more coherent representation of the environment. Multisensory integration, especially when combined with a survey of internal states, provides selective advantages for animals navigating complex environments. Despite appreciation of the importance of multisensory integration in behavior, the underlying molecular and cellular mechanisms remain poorly understood. Recent work looking at how Caenorhabditis elegans makes multisensory decisions has yielded mechanistic insights into how a relatively simple and well-defined nervous system employs circuit motifs of defined features, synaptic signals and extrasynaptic neurotransmission, as well as neuromodulators in processing and integrating multiple sensory inputs to generate flexible and adaptive behavioral outputs.

Indexed as

AnimalsBehavior, AnimalCaenorhabditis elegansSensationSynaptic Transmission

Identifiers

PMID28273525
PMCPMC5501174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.