Evidence map›Paper›PMID 28273468›Full record

ArticleCell metabolism2017

Feeding the Genome: In Silico Optimization of Dietary Amino Acid Composition.

Michael R MacArthur, James R Mitchell

Abstract readComment
In one paragraph

Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The optimal amino acid pattern for humans and its implications for nutrition of cancer patients.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael R MacArthurDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
James R MitchellDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: jmitchel@hsph.harvard.edu.

Funding

Interdisciplinary Training in Genes and the EnvironmentT32ES016645 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LEE, CHIH-HAO · 2008 to 2018
$4.0M
Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
Protection against renal ischemic injury by short term dietary restrictionR01AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2010 to 2014
$1.6M
NIA NIH HHS R01 AG036712NIDDK NIH HHS R01 DK090629NIEHS NIH HHS T32 ES016645
6 · The paper itself

Abstract

Optimizing dietary amino acid ratios to achieve maximal growth and reproduction has historically required tedious empirical studies. In this issue, Piper et al. (2017) present an in silico method of essential amino acid optimization based on the translated portion of an organism's genome, or exome.

Indexed as

Computer SimulationDietAmino AcidsReproductionAmino Acids

Identifiers

PMID28273468
PMCPMC5752111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.