Evidence map›Paper›PMID 28273448›Full record

ArticleCell reports2017

Mutations that Allow SIR2 Orthologs to Function in a NAD

Caitlin R Ondracek, Vincent Frappier, Alison E Ringel, Cynthia Wolberger, Leonard Guarente

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. NADMolecular cell · 2020
    Article
  10. Altered Expression of Mitochondrial NADFrontiers in genetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Caitlin R OndracekGlenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA.
Vincent FrappierKeating Laboratory, Department of Biology, MIT, Cambridge, MA 02139, USA.
Alison E RingelDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Cynthia WolbergerDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Leonard GuarenteGlenn Center for the Science of Aging, Department of Biology, Koch Institute, MIT, Cambridge, MA 02139, USA. Electronic address: leng@mit.edu.
Johns Hopkins University · USMassachusetts Institute of Technology · US

Funding

MOLECULAR STUDY OF YEAST SGS1 AND RDNA CIRCLES IN AGINGR01AG015339 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 1999 to 2014
$5.5M
Function of SIRT1 in Growth and ReproductionR01AG011119 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 1993 to 2016
$2.8M
Molecular Study of sir-2 Genes and Aging in C. elegansR01AG021150 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 2002 to 2011
$2.8M
Function in Mammalian SIRT1 in AgingR56AG015339 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 2016 to 2016
$230k
NIA NIH HHS R01 AG011119NIA NIH HHS R01 AG015339NIA NIH HHS R01 AG021150NIA NIH HHS R56 AG015339
6 · The paper itself

Abstract

Sirtuin enzymes depend on NAD

Indexed as

Sequence Homology, Amino AcidAcetylationHumansKineticsModels, MolecularMutationNADProtein StabilitySaccharomyces cerevisiaeSirtuin 2Substrate SpecificityNADSirtuin 2adaptive mutationsagingkinetic analysesNAD(+)predictive protein modelingSir2SIRT1yeast replicative lifespan

Identifiers

PMID28273448
PMCPMC5407064
OpenAlexW2594117778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.