ArticlePloS one2017
Pulsatile desynchronizing delayed feedback for closed-loop deep brain stimulation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Proportional-Integral Controller-Based Deep Brain Stimulation Strategy for Controlling Excitatory-Inhibitory Network Synchronization.Proceedings of the ... American Control Conference. American Control Conference · 2025Article
- Modeling the modulation of beta oscillations in the basal ganglia by dual-target optogenetic stimulation.Fundamental research · 2025Article
- Magnitude-constrained optimal chaotic desynchronization of neural populations.Frontiers in network physiology · 2025Article
- Article
- Feedback control of collective dynamics in an oscillator population with time-dependent connectivity.Frontiers in network physiology · 2024Article
- Suppression of beta oscillations by delayed feedback in a cortex-basal ganglia-thalamus-pedunculopontine nucleus neural loop model.Journal of biological physics · 2023Article
- Machine learning for adaptive deep brain stimulation in Parkinson's disease: closing the loop.Journal of neurology · 2023Review
- Adaptive Stimulations in a Biophysical Network Model of Parkinson's Disease.International journal of molecular sciences · 2023Article
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation.Frontiers in human neuroscience · 2022Article
- Closing the loop of DBS using the beta oscillations in cortex.Cognitive neurodynamics · 2021Article
- Technology of deep brain stimulation: current status and future directions.Nature reviews. Neurology · 2021Review
- Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters.Frontiers in physiology · 2021Article
- Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review.Bioelectricity · 2020Review
- Fractional order controllers increase the robustness of closed-loop deep brain stimulation systems.Chaos, solitons, and fractals · 2020Article
- Long-Lasting Desynchronization of Plastic Neural Networks by Random Reset Stimulation.Frontiers in physiology · 2020Article
- Adaptive delivery of continuous and delayed feedback deep brain stimulation - a computational study.Scientific reports · 2019Article
- Article
- Controlling Synchronization of Spiking Neuronal Networks by Harnessing Synaptic Plasticity.Frontiers in computational neuroscience · 2019Article
- A neural mass model to predict electrical stimulation evoked responses in human and non-human primate brain.Journal of neural engineering · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-frequency (HF) deep brain stimulation (DBS) is the gold standard for the treatment of medically refractory movement disorders like Parkinson's disease, essential tremor, and dystonia, with a significant potential for application to other neurological diseases. The standard setup of HF DBS utilizes an open-loop stimulation protocol, where a permanent HF electrical pulse train is administered to the brain target areas irrespectively of the ongoing neuronal dynamics. Recent experimental and clinical studies demonstrate that a closed-loop, adaptive DBS might be superior to the open-loop setup. We here combine the notion of the adaptive high-frequency stimulation approach, that aims at delivering stimulation adapted to the extent of appropriately detected biomarkers, with specifically desynchronizing stimulation protocols. To this end, we extend the delayed feedback stimulation methods, which are intrinsically closed-loop techniques and specifically designed to desynchronize abnormal neuronal synchronization, to pulsatile electrical brain stimulation. We show that permanent pulsatile high-frequency stimulation subjected to an amplitude modulation by linear or nonlinear delayed feedback methods can effectively and robustly desynchronize a STN-GPe network of model neurons and suggest this approach for desynchronizing closed-loop DBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.