ArticlePloS one2017
Relationships between social isolation, neighborhood poverty, and cancer mortality in a population-based study of US adults.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Social isolation and social connectedness among young adult cancer survivors: A systematic review.Cancer · 2023Pooled it
- A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality.Nature human behaviour · 2023Pooled it
- Pooled it
- Trial
- The prognostic value of patient-reported outcomes in allogeneic hematopoietic stem cell transplantation: exploratory analysis of a randomized nutrition intervention trial.Annals of hematology · 2023Trial
- A randomized control trial to test a peer support group approach for reducing social isolation and depression among female Mexican immigrants.BMC public health · 2021Trial
- The role of rurality and area-level disadvantage in lifestyle risk factors and psychological well-being among cancer survivors: findings from the 2021 NCI HINTS-SEER.Cancer causes & control : CCC · 2026Article
- Article
- Social support and epigenetic aging at the intersections of race, ethnicity, and gender: findings from NHANES 1999-2002.SSM - population health · 2026Article
- Social Isolation and Incidence of Chest Pain and Mortality in Older Adults of the United States Population: A Cross-Sectional Study From NHANES 2001-2018.Health science reports · 2026Article
- Cancer Burden in Persistent Poverty Areas across the Cancer Continuum: A Scoping Review to Identify Gaps and Opportunities for Future Research.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Social isolation and loneliness and mortality among cancer survivors: a prospective cohort study.Frontiers in oncology · 2026Article
- Exploring the versatility ofFly · 2025Review
- Development and Validation of a Natural Language Processing Algorithm Using Electronic Health Record Data to Identify Breast Cancer Patients With Low Social Support.JCO oncology advances · 2025Article
- Cancer Patients' Social Relationships During 3 Years After Diagnosis-Generic and Cancer-Specific Social Networks.International journal of behavioral medicine · 2025Article
- Article
- Loneliness among adult cancer survivors in the United States: prevalence and correlates.Scientific reports · 2025Article
- Chronic loneliness and isolation phenotypes, incident functional impairment and mortality in England between 2004 and 2018.Nature. Mental health · 2025Article
- Article
- The Association Between Socioeconomic Factors at Diagnosis and Survival in Medulloblastoma: A Propensity Score-Matched Analysis and Population-Based Study.Journal of racial and ethnic health disparities · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSocial isolation is an important determinant of all-cause mortality, with evidence suggesting an association with cancer-specific mortality as well. In this study, we examined the associations between social isolation and neighborhood poverty (independently and jointly) on cancer mortality in a population-based sample of US adults.
methodsUsing data from the Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994), NHANES III Linked Mortality File (through 2011) and 1990 Census, we estimated the relationship between social isolation and high neighborhood poverty and time-to-cancer death using multivariable-adjusted Cox proportional hazards models. We examined the associations of each factor independently and explored the multiplicative and additive interaction effects on cancer mortality risk and also analyzed these associations by sex.
resultsAmong 16 044 US adults with 17-23 years of follow-up, there were 1133 cancer deaths. Social isolation (HR 1.25, 95% CI: 1.01-1.54) and high neighborhood poverty (HR 1.31, 95% CI: 1.08-1.60) were associated with increased risk of cancer mortality adjusting for age, sex, and race/ethnicity; in sex-specific estimates this increase in risk was evident among females only (HR 1.39, 95% CI: 1.04-1.86). These associations were attenuated upon further adjustment for socioeconomic status. There was no evidence of joint effects of social isolation and high neighborhood poverty on cancer mortality overall or in the sex-stratified models.
conclusionsThese findings suggest that social isolation and higher neighborhood poverty are independently associated with increased risk of cancer mortality, although there is no evidence to support our a priori hypothesis of a joint effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.