ArticlePloS one2017
Ultra structural changes occurring in duct ectasia and periductal mastitis and their significance in etiopathogenesis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Targeted Duct Excision Reduces Recurrence and Shortens Treatment Duration in Periductal Mastitis: A Retrospective Cohort Study.International journal of women's health · 2026Article
- Research Progress of Plasma Cell Mastitis.Immunity, inflammation and disease · 2025Review
- Mechanisms of EMT in the immune microenvironment of plasma cell mastitis.Frontiers in immunology · 2025Review
- Identification of periductal mastitis and granulomatous lobular mastitis: a literature review.Annals of translational medicine · 2023Review
- Current Understanding and Management of Plasma Cell Mastitis: Can We Benefit from What We Know?Breast care (Basel, Switzerland) · 2022Review
- Modified techniques versus Hadfield's procedure in patients with periductal mastitis.BMC surgery · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuct ectasia (DE) and periductal mastitis (PDM) are the most common benign breast conditions seen in women. The etiopathogenesis of these entities is still not clear and most of the theories regarding the causation are based on the histological features as seen on light microscopy. The ultramicroscopic features associated with these conditions that may give more insight to the etiopathogenesis are unknown.
aimTo study the ultrastructural changes occurring in mammary duct cones in patients with DE and PDM using Transmission Electron Microscopic (TEM).
methodMajor ducts removed by radical duct excision from 21 patients with final histopathological diagnosis of DE and PDM were subjected to TEM study with 2 normal duct samples as controls.
resultsThe TEM features of DE were denudation of the epithelial cells with focal loss of microvilli, widening of the inter-epithelial junctions with focal disruption of the T bars, periductal collagenisation without inflammation, and features suggestive of Epithelial Mesenchymal Transition (EMT). PDM features are intact epithelial lining with proliferative epithelium and periductal collagenisation with inflammation.
conclusionsBased on the TEM findings, we suggest that DE and PDM are two different entities. EMT a novel finding observed in DE in this study.
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Registered trials
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