ArticlePloS one2017
Age-related differences in skeletal muscle microvascular response to exercise as detected by contrast-enhanced ultrasound (CEUS).
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05608824 (Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using Shear Wave Elastography and Micro-vascular Flow Imaging), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using Shear Wave Elastography and Micro-vascular Flow Imaging
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults.Sports medicine (Auckland, N.Z.) · 2025Trial
- Long-Term Aspirin Use and Self-Reported Walking Speed in Older Men: The Physicians' Health Study.The Journal of frailty & aging · 2022Trial
- Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults.GeroScience · 2021Trial
- Correlation Analysis of Lower Limb Contrast-Enhanced Ultrasound Findings With Serum VEGF and CXCL-12 Levels in a Rabbit Model of Diabetic Foot.BioMed research international · 2026Article
- Case Study on Skin Calorimetry: Modeling Localized Muscle Heat Transfer During Exercise.Biosensors · 2025Article
- Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert's curve.Scientific reports · 2025Article
- Photoacoustic imaging: a unique imaging examination for the assessment of diabetic vascular disease.Frontiers in clinical diabetes and healthcare · 2025Review
- Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.bioRxiv : the preprint server for biology · 2024Article
- Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.NAR molecular medicine · 2024Article
- Type II Muscle Fiber Capillarization Is an Important Determinant of Post-Exercise Microvascular Perfusion in Older Adults.Gerontology · 2024Article
- Contrast-enhanced ultrasound for musculoskeletal indications in children.Pediatric radiology · 2021Review
- Skeletal Muscle and Childhood Cancer: Where are we now and where we go from here.Aging and cancer · 2021Article
- Skeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age.Physiological reports · 2020Article
- Evaluation of capillary blood volume in the lower limb muscles after exercise by intravoxel incoherent motion.La Radiologia medica · 2020Article
- Lifelong Endurance Exercise as a Countermeasure Against Age-RelatedSports medicine (Auckland, N.Z.) · 2020Review
- Photobiomodulation 30 min or 6 h Prior to Cycling Does Not Alter Resting Blood Flow Velocity, Exercise-Induced Physiological Responses or Time to Exhaustion in Healthy Men.Frontiers in physiology · 2020Article
- The role of the microcirculation in muscle function and plasticity.Journal of muscle research and cell motility · 2019Review
- The Effect of Exercise on Glucoregulatory Hormones: A Countermeasure to Human Aging: Insights from a Comprehensive Review of the Literature.International journal of environmental research and public health · 2019Review
- The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals.Frontiers in physiology · 2019Article
- Cardiovascular aging and the microcirculation of skeletal muscle: using contrast-enhanced ultrasound.American journal of physiology. Heart and circulatory physiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging involves reductions in exercise total limb blood flow and exercise capacity. We hypothesized that this may involve early age-related impairments of skeletal muscle microvascular responsiveness as previously reported for insulin but not for exercise stimuli in humans.
methodsUsing an isometric exercise model, we studied the effect of age on contrast-enhanced ultrasound (CEUS) parameters, i.e. microvascular blood volume (MBV), flow velocity (MFV) and blood flow (MBF) calculated from replenishment of Sonovue contrast-agent microbubbles after their destruction. CEUS was applied to the vastus lateralis (VLat) and intermedius (VInt) muscle in 15 middle-aged (MA, 43.6±1.5 years) and 11 young (YG, 24.1±0.6 years) healthy males before, during, and after 2 min of isometric knee extension at 15% of peak torque (PT). In addition, total leg blood flow as recorded by femoral artery Doppler-flow. Moreover, fiber-type-specific and overall capillarisation as well as fiber composition were additionally assessed in Vlat biopsies obtained from CEUS site. MA and YG had similar quadriceps muscle MRT-volume or PT and maximal oxygen uptake as well as a normal cardiovascular risk factors and intima-media-thickness.
resultsDuring isometric exercise MA compared to YG reached significantly lower levels in MFV (0.123±0.016 vs. 0.208±0.036 a.u.) and MBF (0.007±0.001 vs. 0.012±0.002 a.u.). In the VInt the (post-occlusive hyperemia) post-exercise peaks in MBV and MBF were significantly lower in MA vs. YG. Capillary density, capillary fiber contacts and femoral artery Doppler were similar between MA and YG.
conclusionsIn the absence of significant age-related reductions in capillarisation, total leg blood flow or muscle mass, healthy middle-aged males reveal impaired skeletal muscle microcirculatory responses to isometric exercise. Whether this limits isometric muscle performance remains to be assessed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.