ArticlePLoS genetics2017
Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Pharmacological protection from a sugar-rich diet through inhibition of Ras/MAPK signaling.iScience · 2026Article
- Phosphatidic Acid Reverses Obesity Induced by a High-Fat, High-Sugar Diet at the Transcriptional Level.Genes · 2025Article
- LncRNA938/ TAF9/TTK axis promotes EMT and serves as a therapeutic target in hepatoblastoma.Journal of translational medicine · 2025Article
- Alanine metabolism mediates energy allocation of the brown planthopper to adapt to resistant rice.Journal of advanced research · 2025Article
- TBP activates DCBLD1 transcription to promote cell cycle progression in cervical cancer.Functional & integrative genomics · 2024Article
- Neuronal fatty acid-binding protein enhances autophagy and suppresses amyloid-β pathology in a Drosophila model of Alzheimer's disease.PLoS genetics · 2024Article
- TATA-binding associated factors have distinct roles during early mammalian development.Developmental biology · 2024Article
- Wds-Mediated H3K4me3 Modification Regulates Lipid Synthesis and Transport inInternational journal of molecular sciences · 2023Article
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- Parasite reliance on its host gut microbiota for nutrition and survival.The ISME journal · 2022Article
- Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans.The Journal of biological chemistry · 2022Article
- An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.EMBO reports · 2022Article
- Phenotyping ofBiomolecules · 2022Review
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- A conserved role ofPeerJ · 2022Article
- A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila.PLoS genetics · 2021Article
- Theaflavin-regulated Imd condensates controliScience · 2021Article
- Activation of TAF9Frontiers in pharmacology · 2021Article
- TATA-Box Binding Protein O-GlcNAcylation at T114 Regulates Formation of the B-TFIID Complex and Is Critical for Metabolic Gene Regulation.Molecular cell · 2020Article
- Rosy Beginnings: Studying Peroxisomes inFrontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The general transcription factor TBP (TATA-box binding protein) and its associated factors (TAFs) together form the TFIID complex, which directs transcription initiation. Through RNAi and mutant analysis, we identified a specific TBP family protein, TRF2, and a set of TAFs that regulate lipid droplet (LD) size in the Drosophila larval fat body. Among the three Drosophila TBP genes, trf2, tbp and trf1, only loss of function of trf2 results in increased LD size. Moreover, TRF2 and TAF9 regulate fatty acid composition of several classes of phospholipids. Through RNA profiling, we found that TRF2 and TAF9 affects the transcription of a common set of genes, including peroxisomal fatty acid β-oxidation-related genes that affect phospholipid fatty acid composition. We also found that knockdown of several TRF2 and TAF9 target genes results in large LDs, a phenotype which is similar to that of trf2 mutants. Together, these findings provide new insights into the specific role of the general transcription machinery in lipid homeostasis.
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