Evidence map›Paper›PMID 28273006›Full record

ArticleHuman vaccines & immunotherapeutics2017

Viral interference and the live-attenuated intranasal influenza vaccine: Results from a pediatric cohort with cystic fibrosis.

Constantina Boikos, Jesse Papenburg, Christine Martineau, Lawrence Joseph, David Scheifele, Mark Chilvers, Larry C Lands, Gaston De Serres, Caroline Quach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Constantina Boikosa Department of Epidemiology , Biostatistics & Occupational Health, McGill University , Montreal , QC , Canada.
Jesse Papenburgb Department of Pediatrics , Division of Infectious Diseases, The Montreal Children's Hospital, McGill University , Montreal , QC , Canada.
Christine Martineauc Laboratoire de santé publique du Québec, Institut national de santé publique du Québec , QC , Canada.
Lawrence Josepha Department of Epidemiology , Biostatistics & Occupational Health, McGill University , Montreal , QC , Canada.
David Scheifeled Vaccine Evaluation Center, Child & Family Research Institute, University of British Columbia , BC , Canada.
Mark Chilverse Director, Cystic Fibrosis Clinic, University of British Columbia , BC , Canada.
Larry C Landsf Department of Pediatrics , Division of Respiratory Medicine, The Montreal Children's Hospital, McGill University , Montreal , QC , Canada.
Gaston De Serresg Direction des risques biologiques et de la santé au travail, Institut national de santé publique du Québec , QC , Canada.
Caroline Quacha Department of Epidemiology , Biostatistics & Occupational Health, McGill University , Montreal , QC , Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to explore the effects of viral co-detection in individuals recently vaccinated with the live-attenuated intranasal influenza virus vaccine (LAIV) on the detection of influenza RNA.

methodsBefore the 2013-2014 influenza season, nasal swabs were obtained from 59 pediatric participants with cystic fibrosis (CF) and 17 of their healthy siblings immediately before vaccination and 4 times during the week of follow-up. Real-time RT-PCR assays were used to detect influenza RNA. Co-detection of a non-influenza respiratory virus (NIRV) at the time of vaccination was determined by a multiplex RT-PCR assay. Differences in the proportions and rates of influenza detection and their 95% credible intervals (CrI) were estimated.

resultsInfluenza RNA was detected in 16% fewer participants (95% CrI: -7, 39%) throughout follow-up in the NIRV-positive group compared with the NIRV-negative group (59% vs. 75%). This was also observed in participants with CF alone (66% vs. 74%; RD = 8% 95% CrI: -16, 33%) as well as in healthy participants only (75% vs. 30%; RD = 45%, 95% CrI: -2, 81%). Influenza was detected in NIRV-negative subjects for 0.49 d more compared with NIRV-positive subjects (95% CrI: -0.37, 1.26).

conclusionThe observed proportion of subjects in whom influenza RNA was detected and the duration of detection differed slightly between NIRV- positive and -negative subjects. However, wide credible intervals for the difference preclude definitive conclusions. If true, this observed association may be related to a recent viral respiratory infection, a phenomenon known as viral interference.

Indexed as

Viral InterferenceAdolescentChildChild, PreschoolCystic FibrosisFemaleHumansInfluenza, HumanInfluenza VaccinesMaleMultiplex Polymerase Chain ReactionOrthomyxoviridaeProspective StudiesReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, ViralInfluenza VaccinesRNA, ViralVaccines, Attenuatedchildhood vaccinationcystic fibrosisinfluenza vaccinationlive-attenuated influenza virus vaccineviral interference

Identifiers

PMID28273006
PMCPMC5489283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.