Evidence map›Paper›PMID 28272911›Full record

Trial reportCancer investigation2017

Effect of Cruciferous Vegetable Intake on Oxidative Stress Biomarkers: Differences by Breast Cancer Status.

Michael D Wirth, E Angela Murphy, Thomas G Hurley, James R Hébert

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Cancer investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Isothiocyanates: Translating the Power of Plants to People.Molecular nutrition & food research · 2018
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael D Wirtha Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.
E Angela Murphyd Department of Pathology , Microbiology, and Immunology, School of Medicine, University of South Carolina , Columbia , South Carolina , USA.
Thomas G Hurleyc Connecting Health Innovation, LLC , Columbia , South Carolina , USA.
James R Héberta Department of Epidemiology and Biostatistics , Arnold School of Public Health, University of South Carolina , Columbia , South Carolina , USA.

Funding

HEALTH PROMOTION AND DISEASE PREVENTION RESEARCH CENTERS: CENTER PROPOSAL CAT. 1U48DP001936 · DP · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILCOX, SARA · 2009 to 2013
$7.3M
Expanding Mentoring Capacity in High-Risk PopulationsK05CA136975 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2009 to 2013
$801k
Regulation of Macrophages in Obesity-Enhanced Colon Cancer:Benefits of QuercetinK01AT007824 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MURPHY, ELIZABETH ANGELA · 2013 to 2017
$632k
NCCDPHP CDC HHS U48 DP001936NCCIH NIH HHS K01 AT007824NCI NIH HHS K05 CA136975
6 · The paper itself

Abstract

This post hoc analysis examined cruciferous vegetable intake on urinary oxidative metabolites in postmenopausal women. Intervention participants (n = 69) received cruciferous vegetables (≥14 cups/week) during a 3-week period. First morning urine measured 8-isoprostane and 8-hydroxy-2'-deoxyguanosine. Dietary intake was estimated using 24-h recalls. When stratified by history of breast cancer, those with breast cancer had significantly lower post-intervention urinary 8-hydroxy-2'-deoxyguanosine values in the intervention arm versus. the control arm (1.1 ng/mL vs. 3.2 ng/mL, p = .01) after adjustment for baseline 8-hydroxy-2'-deoxyguanosine. This was not observed in those without breast cancer. Further work is needed to understand the role of breast cancer in these relationships.

Indexed as

BrassicaDiet8-Hydroxy-2'-DeoxyguanosineBiomarkers, TumorBreast NeoplasmsCase-Control StudiesDeoxyguanosineDinoprostFemaleHumansMiddle AgedOxidative Stress8-epi-prostaglandin F2alpha8-Hydroxy-2'-DeoxyguanosineBiomarkers, TumorDeoxyguanosineDinoprostbreast cancerCruciferous vegetablesdieturine lipoprotein oxidation

Identifiers

PMID28272911
PMCPMC5664216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.