Evidence map›Paper›PMID 28272785›Full record

ArticleNMR in biomedicine2017

CEST imaging of fast exchanging amine pools with corrections for competing effects at 9.4 T.

Xiao-Yong Zhang, Feng Wang, Hua Li, Junzhong Xu, Daniel F Gochberg, John C Gore, Zhongliang Zu

Abstract read
In one paragraph

Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiao-Yong ZhangVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8965-1077
Feng WangVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
Hua LiVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
Junzhong XuVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
Daniel F GochbergVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
Zhongliang ZuVanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA.
Vanderbilt University · US

Funding

MRI Diffusion in Tumors Using Oscillating GradientsR01CA109106 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2006 to 2022
$4.0M
CERT Imaging of CancerR01CA184693 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2018
$1.6M
CERT Imaging of MuscleR01EB017767 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2017
$1.4M
MRI of Mobile Protein and Immobile Metabolite via Magnetization Rotation TransferR21EB017873 · NIBIB · VANDERBILT UNIVERSITY · PI ZU, ZHONGLIANG · 2013 to 2014
$424k
NCI NIH HHS R01 CA109106NCI NIH HHS R01 CA184693NIBIB NIH HHS R01 EB017767NIBIB NIH HHS R21 EB017873
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) imaging of fast exchanging amine protons at 3 ppm offset from the water resonant frequency is of practical interest, but quantification of fast exchanging pools by CEST is challenging. To effectively saturate fast exchanging protons, high irradiation powers need to be applied, but these may cause significant direct water saturation as well as non-specific semi-solid magnetization transfer (MT) effects, and thus decrease the specificity of the measured signal. In addition, the CEST signal may depend on the water longitudinal relaxation time (T

Indexed as

AlgorithmsArtifactsAminesAnimalsBiomarkers, TumorBrain NeoplasmsImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMolecular ImagingProton Magnetic Resonance SpectroscopyRatsReproducibility of ResultsSensitivity and SpecificityAminesBiomarkers, Tumorapparent exchange-dependent relaxation with asymmetric analysis (AREX)chemical exchange saturation transfer (CEST)fast exchanging poolsmagnetization transfer ratio with asymmetric analysis (MTRasym)

Identifiers

PMID28272785
PMCPMC5490838
OpenAlexW2593140773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.