Evidence map›Paper›PMID 28272506›Full record

ArticleScientific reports2017

A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection.

Paddy Ssentongo, Anna E Robuccio, Godfrey Thuku, Derek G Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W Billard, Andrew Geronimo, Kurt W Short and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Increasing adult-born neurons protects mice from epilepsy.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Pre-existingFrontiers in molecular neuroscience · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. A Brain-Heart Biomarker for Epileptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Paddy SsentongoCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Anna E RobuccioCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Godfrey ThukuCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Derek G SimCenter for Infectious Disease Dynamics, Penn State University, University Park, Pennsylvania 16802, USA.
Ali NabiCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Fatemeh BahariCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Balaji ShanmugasundaramCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Myles W BillardCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Andrew GeronimoCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Kurt W ShortCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Patrick J DrewCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Jennifer BacconDepartment of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
Steven L WeinsteinDepartment of Neurology, Children's National Medical Center, George Washington University, Washington, DC 20010, USA.
Frank G GilliamDepartment of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
José A StouteDepartment of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.
Vernon M ChinchilliDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
Andrew F ReadCenter for Infectious Disease Dynamics, Penn State University, University Park, Pennsylvania 16802, USA.
Bruce J GluckmanCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Steven J SchiffCenter for Neural Engineering, Penn State University, University Park, Pennsylvania 16802, USA.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · USChildren's National · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.

Indexed as

AnimalsDeath, SuddenDisease Models, AnimalElectroencephalographyEpilepsyMalaria, CerebralMaleMicePlasmodium bergheiSurvival Analysis

Identifiers

PMID28272506
PMCPMC5341121
OpenAlexW2593556066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.