Evidence map›Paper›PMID 28272467›Full record

SynthesisNature communications2017

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.

Stefanie Heilmann-Heimbach, Christine Herold, Lara M Hochfeld, Axel M Hillmer, Dale R Nyholt, Julian Hecker, Asif Javed, Elaine G Y Chew, Sonali Pechlivanis, Dmitriy Drichel and 26 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  9. Androgenetic alopecia.Nature reviews. Disease primers · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
Christine HeroldGerman Center for Neurodegenerative Disorders, 53175 Bonn, Germany.
Lara M HochfeldInstitute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
Axel M HillmerCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Dale R NyholtInstitute of Health and Biomedical Innovation, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia.
Julian HeckerInstitute of Genomic Mathematics, University of Bonn, 53127 Bonn, Germany.
Asif JavedCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Elaine G Y ChewCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Sonali PechlivanisInstitute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, 45122 Essen, Germany.
Dmitriy DrichelCologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Xiu Ting HengCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore.
Ricardo C-H Del RosarioComputational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
Heide L FierInstitute of Genomic Mathematics, University of Bonn, 53127 Bonn, Germany.
Ralf PausDermatology Research Centre, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PL, UK.
Rico RueediDepartment of Computational Biology, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-6713-2214
Tessel E GaleslootRadboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Susanne MoebusInstitute of Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, 45122 Essen, Germany.
Thomas AnhaltInstitute of Human Genetics, University of Bonn, 53127 Bonn, Germany.
Shyam PrabhakarComputational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
Rui LiCentre for Clinical Epidemiology, Departments of Medicine, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2 Canada.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
George PapanikolaouSchool of Health Sciences and Education, Department of Nutrition and Dietetics, Harokopio University, Attica, 17671 Kallithea, Greece.
Zoltán KutalikSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0001-9251-070X
Michael P PhilpottCentre for Cell Biology and Cutaneous Research Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Gérard WaeberDepartment of Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Tim D SpectorDepartment of Twin Research &Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Peter VollenweiderDepartment of Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Lambertus A L M KiemeneyRadboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
George DedoussisSchool of Health Sciences and Education, Department of Nutrition and Dietetics, Harokopio University, Attica, 17671 Kallithea, Greece.
J Brent RichardsCentre for Clinical Epidemiology, Departments of Medicine, Genetics and Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2 Canada.
Michael NothnagelCologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Tim BeckerInstitute for Community Medicine, Ernst Moritz Arndt University Greifswald, 17475 Greifswald, Germany.
David A Hinds23andMe Inc., Mountain View, California 94040, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn, 53127 Bonn, Germany.

Funding

British Heart Foundation RG/14/5/30893
6 · The paper itself

Abstract

Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10

Indexed as

3-Oxo-5-alpha-Steroid 4-DehydrogenaseAdipogenesisAlopeciaCase-Control StudiesFibroblast Growth Factor 5Genetic Association StudiesGenome-Wide Association StudyGenotypeHumansIntercellular Signaling Peptides and ProteinsInterferon Regulatory Factor-4Interferon Regulatory FactorsMaleMelatoninMembrane ProteinsPhenotype3-Oxo-5-alpha-Steroid 4-DehydrogenaseDKK2 protein, humanEBF1 protein, humanFGF5 protein, humanFibroblast Growth Factor 5Intercellular Signaling Peptides and ProteinsInterferon Regulatory Factor-4Interferon Regulatory FactorsMelatoninMembrane ProteinsSRD5A2 protein, humanTrans-Activators

Identifiers

PMID28272467
PMCPMC5344973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.