Evidence map›Paper›PMID 28272426›Full record

ArticleScientific reports2017

Post-translational modifications in PrP expand the conformational diversity of prions in vivo.

Patricia Aguilar-Calvo, Xiangzhu Xiao, Cyrus Bett, Hasier Eraña, Katrin Soldau, Joaquin Castilla, K Peter R Nilsson, Witold K Surewicz, Christina J Sigurdson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Post-translational modifications in prion diseases.Frontiers in molecular neuroscience · 2024
    Review
  6. Review
  7. Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Structural biology of ex vivo mammalian prions.The Journal of biological chemistry · 2022
    Review
  12. Article
  13. Review
  14. Review
  15. Two distinct conformers of PrPActa neuropathologica communications · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Patricia Aguilar-CalvoDepartments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA.
Xiangzhu XiaoDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44116, USA.
Cyrus BettDepartments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA.
Hasier ErañaCIC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, Derio 48160, Spain.
Katrin SoldauDepartments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA.
Joaquin CastillaCIC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, Derio 48160, Spain.
K Peter R NilssonDepartment of Physics, Chemistry, and Biology, Linköping University, Linköping 581 83, Sweden.
Witold K SurewiczDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44116, USA.
Christina J SigurdsonDepartments of Pathology and Medicine, UC San Diego, La Jolla, CA 92093-0612, USA.
University of California, San Diego · USCase Western Reserve University · USCIC bioGUNE · ESLinköping University · SEUniversity of California, Davis · US

Funding

Neuropathology Core - P GambettiP01AI106705 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI · 2014 to 2018
$7.7M
Mechanisms of Prion Aggregation and Species BarriersR01NS069566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, RAVITS, JOHN · 2011 to 2025
$5.7M
Mechanisms of Prion SpreadR01NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2012 to 2021
$3.4M
Structural correlates of prion strain, phenotype and infectivity in human prion dR01NS083687 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI GAMBETTI, PIERLUIGI, SUREWICZ, WITOLD K · 2014 to 2018
$2.9M
NIAID NIH HHS P01 AI106705NINDS NIH HHS R01 NS069566NINDS NIH HHS R01 NS076896NINDS NIH HHS R01 NS083687
6 · The paper itself

Abstract

Misfolded prion protein aggregates (PrP

Indexed as

Protein Processing, Post-TranslationalAnimalsMicePhenotypePregnancy ProteinsPrion DiseasesProtein ConformationPlfr protein, mousePregnancy Proteins

Identifiers

PMID28272426
PMCPMC5341109
OpenAlexW2594343114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.