ArticleScientific reports2017
Troponin-I is present as an essential component of muscles in echinoderm larvae.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Single-nucleus profiling highlights the all-brain echinoderm nervous system.Science advances · 2025Article
- Light-modulated neural control of sphincter regulation in the evolution of through-gut.Nature communications · 2024Article
- A Revised Perspective on the Evolution of Troponin I and Troponin T Gene Families in Vertebrates.Genome biology and evolution · 2023Article
- Evolution of the N-Terminal Regulation of Cardiac Troponin I for Heart Function of Tetrapods: Lungfish Presents an Example of the Emergence of Novel Submolecular Structure to Lead the Capacity of Adaptation.Journal of molecular evolution · 2022Article
- Single-cell RNA sequencing of theeLife · 2021Article
- Sea urchin larvae utilize light for regulating the pyloric opening.BMC biology · 2021Article
- Evolution of nitric oxide regulation of gut function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Deuterostome Genomics: Lineage-Specific Protein Expansions That Enabled Chordate Muscle Evolution.Molecular biology and evolution · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The troponin complex, composed of Troponin-I, Troponin-T and Troponin-C, is an essential mediator of the contraction of striated muscle downstream of calcium signaling in almost all bilaterians. However, in echinoderms and hemichordates, collectively termed Ambulacraria, the components of the troponin complex have never been isolated, thus suggesting that these organisms lost the troponin system during evolution. Here, by analyzing genomic information from sea urchins, we identify the troponin-I gene and isolate its complete mRNA sequence. Using this information, we reveal that the larval muscles express this gene and its translated product and that the protein is definitely a functional molecule expressed in sea urchin larvae by showing that Troponin-I morphants are unable to swallow algae. We conclude that muscular contraction in all bilaterians universally depends on a regulatory system mediated by Troponin-I, which emerged in the common ancestor of bilaterians.
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