Evidence map›Paper›PMID 28272377›Full record

ReviewMolecules (Basel, Switzerland)2017

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal.

Juliana F de Souza, Katiusca da S Pontes, Thais F R Alves, Venâncio A Amaral, Márcia de A Rebelo, Moema A Hausen, Marco V Chaud

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juliana F de SouzaLaboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil. julianafsz@yahoo.com.br.
Katiusca da S PontesLaboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil. katiusca.pontes@outlook.com.
Thais F R AlvesLaboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil. thaisfrancine1@hotmail.com.
Venâncio A AmaralLaboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil. venancio_mt@hotmail.com.
Márcia de A RebeloLaboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil. marciarebelo@ig.com.br.
Moema A HausenLaboratory of Post-Graduate Program in Biotechnology and Environmental Monitoring (PPGBMA), University of São Carlos (UFSCAR), Sorocaba, SP 18052-780, Brazil. mahausen@pucsp.br.
Marco V ChaudLaboratory of Biomaterials and Nanotechnology, University of Sorocaba (UNISO), Sorocaba, SP 18078-005, Brazil. marco.chaud@prof.uniso.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC-drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties.

Indexed as

BiomimeticsBiosensing TechniquesDrug CarriersDrug Delivery SystemsDrug LiberationElasticityEmulsionsLiquid CrystalsPermeabilityViscosityDrug CarriersEmulsionsbiomimetic systemsdrug carriersimmunodetectionliquid crystalslyotropic liquid crystals

Identifiers

PMID28272377
PMCPMC6155424

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.