ArticleMedicine2017
Single-nucleotide polymorphism rs1058205 of KLK3 is associated with the risk of prostate cancer: A case-control study of Han Chinese men in Northeast China.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness.Communications medicine · 2026Article
- Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population.Pathology oncology research : POR · 2020Article
- Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.BMC medical genetics · 2020Article
- Article
- Association between three genetic variants in kallikrein 3 and prostate cancer risk.Bioscience reports · 2018Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundProstate cancer (PCa) is a serious public health concern for men worldwide. However, the risk factors for PCa remain largely unclear. Aim of this study was to investigate statistical associations between the risk of prostate cancer and the rs1058205 single-nucleotide polymorphism (SNP) of the KLK3 gene, which encodes the prostate specific antigen (PSA), in a case-control study of Han Chinese men in Northeast China.
methodsUsing a high-resolution melting curve genotyping method, we determined the genotype and allele distributions of rs1058205 in 2 groups of Han Chinese men, consisting of 268 PCa patients and 298 healthy control subjects. Logistic regression was used to evaluate associations between rs1058205 genotypes and the risk of PCa. Tumor staging and Gleason score were included in a stratified analysis of PCa risk.
resultsThe frequency of the TC genotype of rs1058205 in the PCa group was significantly lower than that in the control group (P = 0.049). The serum PSA level in participants with the TC genotype was significantly lower than that of the TT and CC genotypes in both the PCa and control groups (P < 0.010 for both). The TT genotype was associated with PCa, both with and without adjustment for age (P < 0.010 and P = 0.047, respectively). The TT genotype was also associated with the moderate- and high-risk PCa categories (P = 0.007 and 0.027, respectively).
conclusionThe TT genotype may represent a useful biomarker for identifying high risk of PCa and as a postoperative prognosticator in Chinese PCa patients.
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