Observational studyMedicine2017
Predictive factors and clinical practice profile for strictures post-necrotising enterocolitis.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A meta-analysis on the predictive role of CRP in NEC diagnosis and prognosis.Italian journal of pediatrics · 2025Pooled it
- The bowel loss was preserved with surgical intervention based on multi-item scoring in infants with necrotizing enterocolitis.Frontiers in surgery · 2026Article
- Single-Incision paediatric laparoscopy-Assisted for the treatment of postnecrotizing enterocolitis colonic strictures: a single-centre retrospective study.BMC pediatrics · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Predictive value of biomarkers in neonatal necrotizing enterocolitis.Frontiers in pediatrics · 2025Review
- Predicting risk factors for postoperative intestinal stenosis in neonates with necrotizing enterocolitis: development and assessment of a predictive nomogram.Pediatric surgery international · 2024Article
- Observational
- A time series algorithm to predict surgery in neonatal necrotizing enterocolitis.BMC medical informatics and decision making · 2024Article
- Fecal calprotectin as a non-invasive marker for the prediction of post-necrotizing enterocolitis stricture.Pediatric surgery international · 2023Article
- Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Expression and possible role of Smad3 in postnecrotizing enterocolitis stricture.World journal of pediatric surgery · 2022Article
- Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study.Frontiers in surgery · 2022Article
- Expression and Possible Role of Silent Mating Type Information Regulation 2 Homolog 1 in Post-necrotizing Enterocolitis StrictureFrontiers in pediatrics · 2022Article
- Optimizing Nutritional Strategies to Prevent Necrotizing Enterocolitis and Growth Failure after Bowel Resection.Nutrients · 2021Review
- Serum galectin-3 level as a marker for diagnosis and prognosis of neonatal necrotising enterocolitis: a cohort study.American journal of translational research · 2021Article
- Clinical significance of positive fecal occult blood test in neonates.Scientific reports · 2019Article
- [Changes in C-reactive protein and procalcitonin levels in neonates with necrotizing enterocolitis and their clinical significance].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Early postoperative outcomes of surgery for intestinal perforation in NEC based on intestinal location of disease.Medicine · 2018Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal stricture is a severe and common complication of necrotizing enterocolitis (NEC), causing severe and prolonged morbidity. Our goal was to investigate the clinical predictors for strictures developing after NEC and evaluate the management outcome of the post-NEC strictures to better orient their medicosurgical care.A total of 188 patients diagnosed with NEC with identical treatment protocols throughout the period under study were retrospectively reviewed from 4 academic neonatal centers between from January 1, 2011, and October 31, 2016. Clinical predictive factors and clinical outcomes, including demographic information, clinical management, laboratory data, histopathology of resected bowel segment, and discharge summaries, were evaluated on the basis of with post-NEC strictures or not.Of the involved variables examined, the late-onset NEC [risk ratio (RR), 0.56; 95% confidence interval (95% CI), 0.41-0.92; P < 0.001], cesarean delivery (RR, 1.42; 95% CI, 0.98-2.29; P = 0.026), and first procalcitonin (PCT) (onset of symptoms) (RR, 1.82; 95% CI, 0.98-3.15; P = 0.009) were the independent predictive factors for the post-NEC strictures. C-reactive protein (CRP), white blood cell (WBC), and plateletcrit levels were markedly higher on infants with stricture and elevated levels were maintained until the stricture was healed. Infants with intestinal stricture had significantly longer times to beginning enteral feeds (23.9 ± 12.1), than infants without intestinal stricture (18.6 ± 8.8) (P = 0.023). The median age at discharge was also significantly higher in the group with stricture (P = 0.014).This retrospective and multicenter study demonstrates that the early-onset NEC and cesarean delivery conferred protection over the post-NEC stricture. Infants with post-NEC stricture need prolonged hospitalization.
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