ArticleeLife2017
Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Cellular diversity of the developing chick trigeminal ganglion at single-cell resolution.bioRxiv : the preprint server for biology · 2026Article
- Epiblast-derived CX3CR1+ progenitors generate cardiovascular cells during cardiogenesis.The EMBO journal · 2025Article
- Early coordination of cell migration and cardiac fate determination during mammalian gastrulation.The EMBO journal · 2025Article
- The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish.Nature communications · 2024Article
- Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.EMBO reports · 2023Article
- Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5.Nature communications · 2023Article
- Response to Matters Arising: Intercellular genetic tracing of cardiac endothelium in the developing heart.Developmental cell · 2023Article
- Imaging Approaches and the Quantitative Analysis of Heart Development.Journal of cardiovascular development and disease · 2023Review
- Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart.The Journal of cell biology · 2022Article
- Endocardial Regulation of Cardiac Development.Journal of cardiovascular development and disease · 2022Review
- The Chicken as a Model Organism to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020Review
- Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution.Nature cell biology · 2020Article
- A Bird's Eye View on the Origin of Aortic Hemogenic Endothelial Cells.Frontiers in cell and developmental biology · 2020Article
- Article
- Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.Scientific reports · 2019Article
- Endocardially Derived Macrophages Are Essential for Valvular Remodeling.Developmental cell · 2019Article
- Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development.Genome research · 2019Article
- Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019Review
- Cells with hematopoietic potential reside within mouse proepicardium.Histochemistry and cell biology · 2018Article
- HIC2 regulates isoform switching during maturation of the cardiovascular system.Journal of molecular and cellular cardiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spatio-temporal dynamics of cardiovascular progenitor populations. We show that expression of the cardiac transcription factor
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.