Evidence map›Paper›PMID 28271846›Full record

ReviewLancet (London, England)2017

Non-communicable disease syndemics: poverty, depression, and diabetes among low-income populations.

Emily Mendenhall, Brandon A Kohrt, Shane A Norris, David Ndetei, Dorairaj Prabhakaran

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04646408 (Determinants of Cardiovascular Disease, Kidney Disease and Diabetes in People of African Ancestry With HIV), which is not on this map. Cited by 251 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
251citing papers in PubMed, 11 pooled it
207.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04646408 unknown statusnot on this mapstarted 2020, after this paper: background citation

Determinants of Cardiovascular Disease, Kidney Disease and Diabetes in People of African Ancestry With HIV (CKD Study)

TypeobservationalSponsorKing's College Hospital NHS TrustRan2020 to 2022Enrolled400ConditionsCardiovascular Diseases, Diabetes Mellitus, Chronic Kidney Diseases
3 · Its place in the literature

Who cites it

251 citing papers in PubMed, 11 syntheses or guidelines pooled it, 553 citations in OpenAlex.

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191 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Emily MendenhallSchool of Foreign Service, Georgetown University, Washington, DC, USA. Electronic address: em1061@georgetown.edu.
Brandon A KohrtDepartment of Psychiatry, Duke Global Health Institute, Duke University, Durham, NC, USA.
Shane A NorrisMRC Developmental Pathways for Health Research Unit, Faculty of Health, University of the Witwatersrand, Johannesburg, South Africa.
David NdeteiDepartment of Psychiatry, University of Nairobi, Nairobi, Kenya; Africa Mental Health Foundation, Nairobi, Kenya.
Dorairaj PrabhakaranPublic Health Foundation of India, Centre for Chronic Disease Control, New Delhi, India; London School of Hygiene & Tropical Medicine, London, UK.
Duke Institute for Health Innovation · USGeorgetown University · USLondon School of Hygiene & Tropical Medicine · GBUniversity of Nairobi · KEUniversity of the Witwatersrand · ZA

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Reducing Barriers to Mental Health Task SharingK01MH104310 · NIMH · GEORGE WASHINGTON UNIVERSITY · PI KOHRT, BRANDON ALAN · 2014 to 2018
$908k
FIC NIH HHS R24 TW007988NIMH NIH HHS K01 MH104310
6 · The paper itself

Abstract

The co-occurrence of health burdens in transitioning populations, particularly in specific socioeconomic and cultural contexts, calls for conceptual frameworks to improve understanding of risk factors, so as to better design and implement prevention and intervention programmes to address comorbidities. The concept of a syndemic, developed by medical anthropologists, provides such a framework for preventing and treating comorbidities. The term syndemic refers to synergistic health problems that affect the health of a population within the context of persistent social and economic inequalities. Until now, syndemic theory has been applied to comorbid health problems in poor immigrant communities in high-income countries with limited translation, and in low-income or middle-income countries. In this Series paper, we examine the application of syndemic theory to comorbidities and multimorbidities in low-income and middle-income countries. We employ diabetes as an exemplar and discuss its comorbidity with HIV in Kenya, tuberculosis in India, and depression in South Africa. Using a model of syndemics that addresses transactional pathophysiology, socioeconomic conditions, health system structures, and cultural context, we illustrate the different syndemics across these countries and the potential benefit of syndemic care to patients. We conclude with recommendations for research and systems of care to address syndemics in low-income and middle-income country settings.

Indexed as

CoinfectionDepressive DisorderDiabetes Mellitus, Type 2Economic DevelopmentHIV InfectionsHumansNoncommunicable DiseasesPovertyRisk FactorsSocioeconomic FactorsSyndrome

Identifiers

PMID28271846
PMCPMC5491333
OpenAlexW2593297402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.