ReviewZoological research2017
Consequences of early adverse rearing experience(EARE) on development: insights from non-human primate studies.
Review in Zoological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- An Overview of Depression Pathogenesis: Prevailing Hypotheses and Associated Neurobiological Underpinnings Primarily Evidenced by Rodent Studies.Depression and anxiety · 2026Review
- Early maternal separation potentiates the impact of later social isolation in inducing depressive-like behavior via oxidative stress in adult rats.Psychopharmacology · 2025Article
- Does the Post-Natal Social Environment Influence Cognitive Development in a Social Gecko?Ecology and evolution · 2025Article
- Reconsidering the nature of threat in infancy: Integrating animal and human studies on neurobiological effects of infant stress.Neuroscience and biobehavioral reviews · 2024Review
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Stress (Amsterdam, Netherlands) · 2024Article
- Differential effects of early life adversity on male and female rhesus macaque lifespan.Ecology and evolution · 2023Article
- Are hair cortisol levels dependent on hair growth rate? A pilot study in rhesus macaques.General and comparative endocrinology · 2023Article
- Characterizing the personality and gray matter volume of chimpanzees that exhibit autism-related socio-communicative phenotypes.Personality neuroscience · 2023Article
- Incentive disengagement and the adaptive significance of frustrative nonreward.Learning & behavior · 2022Review
- Nine Levels of Explanation : A Proposed Expansion of Tinbergen's Four-Level Framework for Understanding the Causes of Behavior.Human nature (Hawthorne, N.Y.) · 2021Article
- Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin.Neuropharmacology · 2021Review
- Childhood socio-economic disadvantage predicts reduced myelin growth across adolescence and young adulthood.Human brain mapping · 2020Article
- Increased attention to snake images in cynomolgus monkeys: an eye-tracking study.Zoological research · 2020Article
- Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys.Psychopharmacology · 2019Article
- Enriching Communicative Environments: Leveraging Advances in Neuroplasticity for Improving Outcomes in Neurogenic Communication Disorders.American journal of speech-language pathology · 2019Review
- The Role of the Lateral Hypothalamus in Violent Intraspecific Aggression-The Glucocorticoid Deficit Hypothesis.Frontiers in systems neuroscience · 2018Review
- Comparative study of the transfection efficiency of commonly used viral vectors in rhesus monkey (Zoological research · 2017Article
- Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early rearing experiences are important in one's whole life, whereas early adverse rearing experience(EARE) is usually related to various physical and mental disorders in later life. Although there were many studies on human and animals, regarding the effect of EARE on brain development, neuroendocrine systems, as well as the consequential mental disorders and behavioral abnormalities, the underlying mechanisms remain unclear. Due to the close genetic relationship and similarity in social organizations with humans, non-human primate(NHP) studies were performed for over 60 years. Various EARE models were developed to disrupt the early normal interactions between infants and mothers or peers. Those studies provided important insights of EARE induced effects on the physiological and behavioral systems of NHPs across life span, such as social behaviors(including disturbance behavior, social deficiency, sexual behavior, etc), learning and memory ability, brain structural and functional developments(including influences on neurons and glia cells, neuroendocrine systems, e.g., hypothalamic-pituitary-adrenal(HPA) axis, etc). In this review, the effects of EARE and the underlying epigenetic mechanisms were comprehensively summarized and the possibility of rehabilitation was discussed.
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