Evidence map›Paper›PMID 28271621›Full record

ArticleStem cells translational medicine2017

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential.

Carolina Balbi, Martina Piccoli, Lucio Barile, Andrea Papait, Andrea Armirotti, Elisa Principi, Daniele Reverberi, Luisa Pascucci, Pamela Becherini, Luigi Varesio and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04202783 (The Use of Exosomes In Craniofacial Neuralgia), which is not on this map. Cited by 83 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04202783 nasuspendednot on this mapstarted 2023, after this paper: background citation

The Use of Exosomes In Craniofacial Neuralgia

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2023 to 2024Enrolled100ConditionsNeuralgiaArmsExosomes
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carolina BalbiRegenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.
Martina PiccoliStem Cells and Regenerative Medicine Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
Lucio BarileLaboratory of Molecular and Cellular Cardiology, CardioCentro Ticino Foundation_CCT, Lugano Switzerland.
Andrea PapaitRegenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.
Andrea ArmirottiDrug Discovery and Development Department, IIT-Fondazione Istituto Italiano di Tecnologia, Genova, Italy.
Elisa PrincipiRegenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.
Daniele ReverberiMolecular Pathology Unit, IRCCS AOU San Martino - IST National Institute for Cancer Research, Genova, Italy.
Luisa PascucciVeterinary Medicine Department, University of Perugia, Perugia, Italy.
Pamela BecheriniMolecular Biology Laboratory, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Luigi VaresioMolecular Biology Laboratory, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Massimo MogniHuman Genetics Laboratory, E.O. Ospedali Galliera, Genova, Italy.
Domenico CovielloHuman Genetics Laboratory, E.O. Ospedali Galliera, Genova, Italy.
Tiziano BandieraDrug Discovery and Development Department, IIT-Fondazione Istituto Italiano di Tecnologia, Genova, Italy.
Michela PozzobonStem Cells and Regenerative Medicine Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.
Ranieri CanceddaRegenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.
Sveva BolliniRegenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and significant regenerative potential in several preclinical models of disease. Nevertheless, little is known about the detailed characterization of their secretome. Herein we show for the first time that hAFS actively release extracellular vesicles (EV) endowed with significant paracrine potential and regenerative effect. c-KIT

Indexed as

Amniotic FluidAnimalsCell DifferentiationCell ProliferationExtracellular VesiclesHumansMaleMiceMice, Inbred C57BLMicroRNAsMuscle, SkeletalMuscular AtrophyStem CellsStem Cell TransplantationMicroRNAsApoptosisExosomesExtracellular vesiclesFetal stem cellsmiRNAParacrine communicationProliferationTissue regeneration

Identifiers

PMID28271621
PMCPMC5442724

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.