Evidence map›Paper›PMID 28271589›Full record

ArticlePediatric diabetes2017

Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria.

M Loredana Marcovecchio, Päivi H Tossavainen, Katharine Owen, Catherine Fullah, Paul Benitez-Aguirre, Stefano Masi, Ken Ong, Helen Nguyen, Scott T Chiesa, R Neil Dalton and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

M Loredana MarcovecchioDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Päivi H TossavainenDepartment of Paediatrics, PEDEGO Research Unit and Medical Research Centre Oulu, Oulu, University Hospital and University of Oulu, Oulu, Finland.
Katharine OwenOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Catherine FullahDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Paul Benitez-AguirreInstitute of Endocrinology and Diabetes, University of Sydney, Sydney, Australia.
Stefano MasiVascular Physiology Unit, Institute of Cardiovascular Science, University College London, London, UK.
Ken OngMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Helen NguyenVascular Physiology Unit, Institute of Cardiovascular Science, University College London, London, UK.
Scott T ChiesaVascular Physiology Unit, Institute of Cardiovascular Science, University College London, London, UK.
R Neil DaltonWellChild Laboratory, King's College London, Evelina Children's Hospital, London, UK.
John DeanfieldVascular Physiology Unit, Institute of Cardiovascular Science, University College London, London, UK.
David B DungerDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2566-9304
University College London · GBUniversity of Cambridge · GBKing's College London · GBOulu University Hospital · FIThe University of Sydney · AUUniversity of Oxford · GB

Funding

British Heart Foundation SP/07/002/23394Medical Research Council G0600717Medical Research Council MC_UU_12012/5Medical Research Council MC_UU_12015/2Wellcome Trust
6 · The paper itself

Abstract

objectiveTo evaluate the association between a clustering of cardio-metabolic risk factors in parents and the development of microalbuminuria (MA) in their offspring with childhood-onset type 1 diabetes (T1D).

methodsThe study population comprised 53 parents (mean age [±SD]: 56.7±6.2 years) of 35 T1D young people with MA (MA+) and 86 parents (age: 56.1±6.3 years) of 50 matched offspring with normoalbuminuria (MA-), who underwent clinical, biochemical and cardiovascular imaging assessments. The primary study endpoint was the difference between parents from the MA+ and MA- groups in a cardio-metabolic risk score, calculated as the average value of the standardized measures (z-scores) for waist circumference, blood pressure, fasting glucose, insulin, HDL-cholesterol and triglycerides levels. Cardiovascular parameters, including carotid intima-media thickness (cIMT), flow-mediated dilatation (FMD) and pulse wave velocity (PWV), were also assessed. A DXA scan was performed to assess body composition.

resultsThe cardio-metabolic risk score was significantly higher in parents of MA+ compared to parents of MA- offspring (mean [95% CI]: 1.066[0.076; 2.056] vs -0.268[-0.997; 0.460], P = .03). Parents of MA+ offspring had slightly higher values of waist circumference, lipids, insulin and blood pressure, although only diastolic blood pressure was statistically different between the 2 groups (P = .0085). FMD, cIMT, PWV (all P > .3), and DXA parameters (all P > .2) were not significantly different between the 2 groups.

conclusionsParents of young offspring with childhood-onset T1D and MA showed an abnormal metabolic profile, reflected by a calculated risk score. The finding supports the role of a familial predisposition to risk of developing diabetic nephropathy.

Indexed as

ParentsAdolescentAlbuminuriaCardiovascular DiseasesCase-Control StudiesChildDiabetes Mellitus, Type 1FemaleHumansMaleMiddle AgedRisk FactorsUnited KingdomYoung Adultcardio-metabolicmicroalbuminuriaparentstype 1 diabetes

Identifiers

PMID28271589
PMCPMC6186416
OpenAlexW2592364667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.