ArticleHepatology (Baltimore, Md.)2017
The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice.
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Article in Hepatology (Baltimore, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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73citing papers in PubMed
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Who cites it
73 citing papers in PubMed.
- Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy.BioMed research international · 2021Trial
- LncRNA H19 as a key regulator in biliary atresia: insights into pathogenesis and potential therapeutic targets.Annals of medicine · 2026Review
- Sexual dimorphism in the liver.Nature reviews. Gastroenterology & hepatology · 2026Review
- Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.The Journal of experimental medicine · 2026Article
- Decoding the role of H19 in cholestatic liver injury using snRNA-seq, spatial transcriptomics, and machine learning-based disease prediction.Cell & bioscience · 2026Article
- Decoding the Role of H19 in Cholestatic Liver Injury Using snRNA-seq, Spatial Transcriptomics, and Machine Learning-Based Disease Prediction.Research square · 2026Article
- Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury.Journal of advanced research · 2026Article
- Multiomics analysis elucidated the role of inflammatory response and bile acid metabolism disturbance in electric shock-induced liver injury in mice.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum CaActa pharmacologica Sinica · 2025Article
- Article
- Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening.Nature communications · 2025Article
- Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes.Hepatology communications · 2025Article
- MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia.European journal of medical research · 2025Article
- Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury inAmerican journal of physiology. Gastrointestinal and liver physiology · 2025Article
- LncRNA H19 promoted alcohol-associated liver disease through dysregulation of alternative splicing and methionine metabolism.Hepatology (Baltimore, Md.) · 2025Article
- LncRNAs, RNA Therapeutics, and Emerging Technologies in Liver Pathobiology.Seminars in liver disease · 2025Review
- Research progress and perspectives of non-coding RNAs in primary biliary cholangitis: from mechanisms to therapeutics.Frontiers in medicine · 2025Review
- Ursodeoxycholic acid acts as an ileal FXR agonist in male mice with hepatic deficiency of FXR.eGastroenterology · 2025Article
- Dynamic role of exosomal long non-coding RNA in liver diseases: pathogenesis and diagnostic aspects.Hepatology international · 2024Review
- Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications.Medical review (2021) · 2024Review
13 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Xiaojiaoyang LiJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Runping LiuDepartment of Microbiology and Immunology, Virginia Commonwealth University, and McGuire Veterans Affairs Medical Center, Richmond, VA.
Jing YangJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Lixin SunJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Luyong ZhangJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Zhenzhou JiangJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, China.
Puneet PuriDivision of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA.
Emily C GurleyDepartment of Microbiology and Immunology, Virginia Commonwealth University, and McGuire Veterans Affairs Medical Center, Richmond, VA.
Guanhua LaiDepartment of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA.
Yuping TangJiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.
Zhiming HuangDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
William M PandakDepartment of Microbiology and Immunology, Virginia Commonwealth University, and McGuire Veterans Affairs Medical Center, Richmond, VA.
Phillip B HylemonDepartment of Microbiology and Immunology, Virginia Commonwealth University, and McGuire Veterans Affairs Medical Center, Richmond, VA.
Huiping ZhouDepartment of Microbiology and Immunology, Virginia Commonwealth University, and McGuire Veterans Affairs Medical Center, Richmond, VA.ORCID 0000-0002-0050-372X
Funding
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0MRegulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismR01DK057543 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2001 to 2015
$4.4MLncRNA H19 in Cholestatic Liver DiseasesR01DK115377 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2018 to 2021
$2.1MBile Acid and Sphingosine-1-phosphate Receptor-mediated Signaling in CholestasisR01DK104893 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2016 to 2020
$2.0MEffect of alcohol on obesity related liver disease: Role of intestinal metabonomeK23AA021179 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI PURI, PUNEET · 2012 to 2016
$882kBLRD VA I01 BX001390BLRD VA IK6 BX004477NCI NIH HHS P30 CA016059NIAAA NIH HHS K23 AA021179NIDDK NIH HHS R01 DK057543NIDDK NIH HHS R01 DK104893NIDDK NIH HHS R01 DK115377
Abstract
The multidrug resistance 2 knockout (Mdr2
conclusionH19 plays a critical role in the disease progression of cholestasis and represents a key factor that causes the gender disparity of cholestatic liver injury in Mdr2
Indexed as
Gene Expression RegulationAnimalsCholangitis, SclerosingCholestasisDisease Models, AnimalDown-RegulationEstrogensFemaleGene Knockout TechniquesGenes, MDRHumansLiver CirrhosisMaleMiceMice, KnockoutMitogen-Activated Protein Kinase 1EstrogensH19 long non-coding RNAMapk1 protein, mouseMitogen-Activated Protein Kinase 1Receptors, LysosphingolipidRNA, Long Noncodingsphingosine-1-phosphate receptor-2, mouseSphingosine-1-Phosphate ReceptorsTaurocholic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.