Evidence map›Paper›PMID 28271445›Full record

ReviewProtein & cell2017

Establishment and function of tissue-resident innate lymphoid cells in the skin.

Jie Yang, Luming Zhao, Ming Xu, Na Xiong

Abstract readReview
In one paragraph

Review in Protein & cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Inflammatory Cues Direct Skin-Resident Type 1 Innate Lymphoid Cells to Adopt a Psoriasis-Promoting Identity.JID innovations : skin science from molecules to population health · 2023
    Article
  3. Article
  4. Activation of CD81Science immunology · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. The Role of the Immune System in Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2019
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jie YangCentre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Luming ZhaoCentre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Ming XuCentre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Na XiongCentre for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. nux1@psu.edu.ORCID 0000-0003-4405-6818

Funding

Functional mechanisms of CCR10 in maintenance of the skin immune homeostasisR01AR064831 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XIONG, NA · 2014 to 2018
$1.8M
Positive Selection-Dependent Skin-Homing of Fetal Thymic Gamma/Delta T CellsR01AI071043 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI XIONG, NA · 2008 to 2012
$1.4M
Training in Animal Models of InflammationT32AI074551 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GIBLIN, PAMELA A · 2011 to 2015
$940k
Positive Selection-Dependent Skin-Homing of Fetal Thymic Gamma/Delta T CellsR56AI071043 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI XIONG, NA · 2007 to 2016
$709k
NIAID NIH HHS R01 AI071043NIAID NIH HHS R56 AI071043NIAID NIH HHS T32 AI074551NIAMS NIH HHS R01 AR064831
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a newly classified family of immune cells of the lymphoid lineage. While they could be found in both lymphoid organs and non-lymphoid tissues, ILCs are preferentially enriched in barrier tissues such as the skin, intestine, and lung where they could play important roles in maintenance of tissue integrity and function and protection against assaults of foreign agents. On the other hand, dysregulated activation of ILCs could contribute to tissue inflammatory diseases. In spite of recent progress towards understanding roles of ILCs in the health and disease, mechanisms regulating specific establishment, activation, and function of ILCs in barrier tissues are still poorly understood. We herein review the up-to-date understanding of tissue-specific relevance of ILCs. Particularly we will focus on resident ILCs of the skin, the outmost barrier tissue critical in protection against various foreign hazardous agents and maintenance of thermal and water balance. In addition, we will discuss remaining outstanding questions yet to be addressed.

Indexed as

AnimalsHumansImmunity, InnateInflammationLymphocytesSkinchemokine receptorhomeostasisinflammationinnate lymphoid cellsmigrationskin

Identifiers

PMID28271445
PMCPMC5498338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.