ArticleWorld journal of microbiology & biotechnology2017
Global protein expression profile response of planktonic Aeromonas hydrophila exposed to chlortetracycline.
Article in World journal of microbiology & biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Repeated sub-MIC exposure and biofilm derivation are associated with resistance development and reduced bactericidal susceptibility in Aeromonas hydrophila KCTC 2358.Molecular biology reports · 2026Article
- First comprehensive proteome analysis of lysine crotonylation in Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts.Proteome science · 2021Article
- Enhanced Biosynthesis of Fatty Acids Is Associated with the Acquisition of Ciprofloxacin Resistance in Edwardsiella tarda.mSystems · 2021Article
- Four LysR-type transcriptional regulator family proteins (LTTRs) involved in antibiotic resistance in Aeromonas hydrophila.World journal of microbiology & biotechnology · 2019Article
- Comparative Extracellular Proteomics ofFrontiers in immunology · 2019Article
- Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis.Frontiers in microbiology · 2018Article
- Quantitative Proteomics Reveals Antibiotics Resistance Function of Outer Membrane Proteins inFrontiers in cellular and infection microbiology · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antibiotics resistance phenomena of Aeromonas hydrophila has become serious economic and public health problems for the world aquaculture industry and human health care. In this study, to investigate the instinct antibiotics adaptive mechanism of this pathogen, iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) based quantitative proteomics technologies were performed to compare the differential expression of A. hydrophila in planktonic status in response to chlortetracycline (CTC) stress and then identified total 1552 proteins including 285 altered proteins with 90 increasing and 195 decreasing abundance proteins. The following bioinformatics analysis showed that many metabolic metabolism pathways such as carbon metabolism, pyruvate metabolism, and glycolysis/gluconeogenesis were trend to down-regulated whereas β-Lactam resistance, RNA degradation, and amino acids biosynthesis processes were more likely to increase in CTC stress. The related pyruvate metabolism and β-Lactam resistance processes in mRNA level were further measured using the q-PCR method. Thus, an understanding of the behaviors of A. hydrophila in response to CTC would be helpful to reveal the antibiotics adaptive mechanism and for the development of novel antibiotics therapy.
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