Evidence map›Paper›PMID 28271324›Full record

ArticleNeurochemical research2017

5-HT6 Receptor Agonist and Antagonist Against β-Amyloid-Peptide-Induced Neurotoxicity in PC-12 Cells.

Anand M Bokare, A K Praveenkumar, Mandar Bhonde, Yogendra Nayak, Ravindra Pal, Rajan Goel

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.Journal of cellular and molecular medicine · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anand M BokareNovel Drug Discovery and Development, Lupin Limited (Research Park), 46A/47A, NandeVillage, Mulshi Taluka, Pune, 412 115, India.
A K PraveenkumarNovel Drug Discovery and Development, Lupin Limited (Research Park), 46A/47A, NandeVillage, Mulshi Taluka, Pune, 412 115, India.
Mandar BhondeNovel Drug Discovery and Development, Lupin Limited (Research Park), 46A/47A, NandeVillage, Mulshi Taluka, Pune, 412 115, India.
Yogendra NayakDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, 576104, India. yogendra.nayak@manipal.edu.ORCID http://orcid.org/0000-0002-0508-1394
Ravindra PalNovel Drug Discovery and Development, Lupin Limited (Research Park), 46A/47A, NandeVillage, Mulshi Taluka, Pune, 412 115, India.
Rajan GoelNovel Drug Discovery and Development, Lupin Limited (Research Park), 46A/47A, NandeVillage, Mulshi Taluka, Pune, 412 115, India.
Lupin Pharmaceuticals (India) · INManipal Academy of Higher Education · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beta-amyloid peptide (Aβ) induced neurotoxicity is considered as a hallmark of the pathogenesis of Alzheimer's disease (AD). The present study demonstrated the neuroprotective role of 5-HT6 receptors against Aβ-induced neurotoxicity in PC-12 cells. The 5-HT6 receptor agonist EMD-386088 and antagonist SB-399885 were used as pharmacological tools. The NMDA receptor antagonist, memantine, was used as reference standard. The Aβ

Indexed as

Amyloid beta-PeptidesAnimalsCell SurvivalDose-Response Relationship, DrugIndolesPC12 CellsPeptide FragmentsPiperazinesPyridinesRatsReceptors, SerotoninSerotonin AntagonistsSerotonin Receptor AgonistsSulfonamides5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indoleAmyloid beta-Peptidesamyloid beta-protein (25-35)IndolesPeptide FragmentsPiperazinesPyridinesReceptors, SerotoninSB 399885serotonin 6 receptorSerotonin AntagonistsSerotonin Receptor AgonistsSulfonamides5-HT6 receptorAlzheimer’s diseaseAβ25−35NeuroprotectionPC-12 cells

Identifiers

PMID28271324
OpenAlexW2593839309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.