ArticleJournal of neural transmission (Vienna, Austria : 1996)2017
Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases.Molecular neurodegeneration · 2025Review
- Editorial: Advancing personalized diagnosis and treatment in Parkinson's disease: integrating biomarkers, neuroimaging, and artificial intelligence.Frontiers in neuroscience · 2025Article
- Altered cerebral perfusion in Parkinson's disease patients with anxiety: an arterial spin labeling MRI study.Frontiers in neurology · 2025Article
- Parkinson's disease cerebrovascular reactivity pattern: A feasibility study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers.Alzheimer's research & therapy · 2024Article
- Associations of Serum Liver Function with Cerebral Blood Flow in Patients with Alzheimer's Disease.Journal of Alzheimer's disease reports · 2024Article
- The impact of body position on neurofluid dynamics: present insights and advancements in imaging.Frontiers in aging neuroscience · 2024Review
- Regional white matter hyperintensity volume in Parkinson's disease and associations with the motor signs.Annals of clinical and translational neurology · 2023Article
- Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Temporal Dynamic Alterations of Regional Homogeneity in Parkinson's Disease: A Resting-State fMRI Study.Biomolecules · 2023Article
- Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning.Magma (New York, N.Y.) · 2022Article
- Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Structural retinal changes in cerebral small vessel disease.Scientific reports · 2022Article
- Cerebral blood flow changes during aging process and in cognitive disorders: A review.The neuroradiology journal · 2021Review
- Regional Neural Activity Changes in Parkinson's Disease-Associated Mild Cognitive Impairment and Cognitively Normal Patients.Neuropsychiatric disease and treatment · 2021Article
- Visual Impairments Are Associated With Retinal Microvascular Density in Patients With Parkinson's Disease.Frontiers in neuroscience · 2021Article
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
- The Role of Neurovascular System in Neurodegenerative Diseases.Molecular neurobiology · 2020Review
- Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson's disease.Parkinsonism & related disorders · 2020Article
- Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years ± 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years ± 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.
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