ArticleEuropean journal of epidemiology2017
Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark.
Article in European journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review on the role of paternal factors in human placental development, function, and pregnancy-related disorders.Journal of assisted reproduction and genetics · 2025Pooled it
- Paternal family history of premature atherosclerotic disease and perinatal death: A population-based cohort study.PloS one · 2025Article
- Exploring the Father's Role in Determining Neonatal Birth Weight: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Mechanisms of Germline Stem Cell Competition across Species.Life (Basel, Switzerland) · 2024Review
- Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes.Journal of clinical medicine · 2024Review
- Investigating the impact of paternal aging on murine sperm miRNA profiles and their potential link to autism spectrum disorder.Scientific reports · 2023Article
- Reproductive axis ageing and fertility in men.Reviews in endocrine & metabolic disorders · 2022Review
- The impact of paternal age on new mutations and disease in the next generation.Fertility and sterility · 2022Review
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Social, demographic and health characteristics of men fathering children at different ages.Scientific reports · 2021Article
- Parental age and preterm birth: a population-based cohort of nearly 3 million California livebirths from 2007 to 2012.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study.Frontiers in endocrinology · 2021Article
- Metabolism in Male Reproductive Aging.Advances in geriatric medicine and research · 2021Article
- Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.Reproductive biology and endocrinology : RB&E · 2020Review
- Stillbirth in Greece during the years of economic crisis: a population-based study.European journal of pediatrics · 2020Article
- Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.Biomedical reports · 2020Article
- Parental age effects on neonatal white matter development.NeuroImage. Clinical · 2020Article
- Article
- Infertility in the Aging Male.Current urology reports · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced paternal age has been associated with a variety of rare conditions and diseases of great public health impact. An increased number of de novo point mutations in sperm with increasing age have been suggested as a mechanism, which would likely also affect fetal viability. We examined the association between paternal age and stillbirth rate in a large nationwide cohort. We identified all pregnancies in Denmark from 1994 to 2010 carried to a gestational age of at least 22 completed weeks (n = 944,031) as registered in national registers and linked to individual register data about the parents. The hazard ratio of stillbirth according to paternal age was estimated, adjusted for maternal age in 1-year categories, year of outcome, and additionally parental educational levels. The relative rate of stillbirth (n = 4946) according to paternal age was found to be J-shaped with the highest hazard ratio for fathers aged more than 40 years when paternal age was modelled using restricted cubic splines. When modelled categorically, the adjusted hazard ratios of stillbirth were as follows: <25, 1.16 (95% confidence interval, CI 1.01-1.34); 25-29, 1.03 (95% CI 0.95-1.11); 35-39, 1.16 (95% CI 1.07-1.26); 40-44, 1.41 (95% CI 1.26-1.59); 45-49, 1.20 (95% CI 0.97-1.49); 50+, 1.58 (95% CI 1.18-2.11), compared with fathers aged 30-34 years. These estimates attenuated slightly when further adjusted for parental education. Our study showed that paternal age was associated with the relative rate of stillbirth in a J-shaped manner with the highest hazard ratios among fathers aged more than 40 years.
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