ReviewFrontiers in cell and developmental biology2017
Gap Junction in the Teleost Fish Lineage: Duplicated Connexins May Contribute to Skin Pattern Formation and Body Shape Determination.
Review in Frontiers in cell and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 28 citations in OpenAlex.
- Chromosome-scale genome of European anchovy (Engraulis encrasicolus L., 1758) and comparative genomics uncover clupeid-specific immune gene expansions.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026Article
- Cell-cell communication as underlying principle governing color pattern formation in teleost fishes.Nature communications · 2026Article
- Iridophore apoptosis mediates socially-regulated developmental color pattern plasticity in an anemonefish.PLoS biology · 2026Article
- Endocytosis and Endocytic Motifs across the Connexin Gene Family.International journal of molecular sciences · 2023Article
- Connexinplexity: the spatial and temporal expression of connexin genes during vertebrate organogenesis.G3 (Bethesda, Md.) · 2022Article
- De novo transcriptome assembly and identification of G-Protein-Coupled-Receptors (GPCRs) in two species of monogenean parasites of fish.Parasite (Paris, France) · 2022Article
- Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region.Cellular and molecular life sciences : CMLS · 2021Article
- Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish.Molecular biology of the cell · 2021Article
- Role of the Connexin C-terminus in skin pattern formation of Zebrafish.BBA advances · 2021Article
- Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation.Frontiers in neuroanatomy · 2020Article
- Draft genome assembly of Tenualosa ilisha, Hilsa shad, provides resource for osmoregulation studies.Scientific reports · 2019Article
- Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets.Physiological reports · 2019Article
- KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence.Frontiers in physiology · 2019Article
- Connexin Communication Compartments and Wound Repair in Epithelial Tissue.International journal of molecular sciences · 2018Review
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Gap junctions are intercellular channels that allow passage of ions and small molecules between adjacent cells. Gap junctions in vertebrates are composed of connexons, which are an assembly of six proteins, connexins. Docking of two connexons on the opposite cell surfaces forms a gap junction between the cytoplasm of two neighboring cells. Connexins compose a family of structurally related four-pass transmembrane proteins. In mammals, there are ~20 connexins, each of which contributes to unique permeability of gap junctions, and mutations of some connexin-encoding genes are associated with human diseases. Zebrafish has been predicted to contain 39 connexin-encoding genes; the high number can be attributed to gene duplication during fish evolution, which resulted in diversified functions of gap junctions in teleosts. The determination of body shapes and skin patterns in animal species is an intriguing question. Mathematical models suggest principle mechanisms explaining the diversification of animal morphology. Recent studies have revealed the involvement of gap junctions in fish morphological diversity, including skin pattern formation and body shape determination. This review focuses on connexins in teleosts, which are integrated in the mathematical models explaining morphological diversity of animal skin patterns and body shapes.
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