Evidence map›Paper›PMID 28271056›Full record

ArticleFrontiers in pediatrics2017

Increasing JAK/STAT Signaling Function of Infant CD4

Myra Grace Dela Peña-Ponce, Jennifer Rodriguez-Nieves, Janice Bernhardt, Ryan Tuck, Neelima Choudhary, Michael Mengual, Katie R Mollan, Michael G Hudgens, Sigal Peter-Wohl, Kristina De Paris

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. How CD4Biomedicines · 2023
    Article
  6. Article
  7. The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  8. Hypoxia-Induced Activation of JAK/STAT3 Signaling Pathway Promotes Trophoblast Cell Viability and Angiogenesis in Preeclampsia.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Myra Grace Dela Peña-PonceDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Jennifer Rodriguez-NievesDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Janice BernhardtDivision of Neonatal Perinatal Medicine, Department of Pediatrics, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Ryan TuckDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Neelima ChoudharyDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Michael MengualDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Katie R MollanLineberger Cancer Center, Center for AIDS Research, University of North Carolina , Chapel Hill, NC , USA.
Michael G HudgensGillings School of Global Public Health, Center for AIDS Research, University of North Carolina , Chapel Hill, NC , USA.
Sigal Peter-WohlDivision of Neonatal Perinatal Medicine, Department of Pediatrics, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
Kristina De ParisDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina , Chapel Hill, NC , USA.
University of North Carolina at Chapel Hill · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Molecular Mechanisms Associated with Immune Maturation in InfantsR01AI100067 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DE PARIS, KRISTINA · 2012 to 2015
$1.8M
ImageStreamX Mark IIS10OD017984 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHER, NANCY C. · 2015 to 2015
$418k
NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI100067NIH HHS S10 OD017984
6 · The paper itself

Abstract

Most infant deaths occur in the first year of life. Yet, our knowledge of immune development during this period is scarce and derived from cord blood (CB) only. To more effectively combat pediatric diseases, a deeper understanding of the kinetics and the factors that regulate the maturation of immune functions in early life is needed. Increased disease susceptibility of infants is generally attributed to T helper 2-biased immune responses. The differentiation of CD4

Indexed as

age-dependent changescytokinesinfant CD4+ T cell developmentJAK/STAT signalingSTAT activation

Identifiers

PMID28271056
PMCPMC5318443
OpenAlexW2590378086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.