ArticleMolecular metabolism2017
Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in
Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The study of metabolic improvement by nutritional intervention controlling endogenous GIP (Mini Egg study): a randomized, cross-over study.Nutrition journal · 2019Trial
- Soy Protein Outperforms Whey Protein in Ameliorating Insulin Resistance but Not Obesity in High-Fat Diet-Induced Obese Mice.Nutrients · 2025Article
- Physiology and clinical applications of GIP.Endocrine journal · 2025Review
- The role of GIPR in food intake control.Frontiers in endocrinology · 2025Review
- Gut-Brain Axis Modulation of Metabolic Disorders: Exploring the Intertwined Neurohumoral Pathways and Therapeutic Prospects.Neurochemical research · 2024Review
- Intestinal Morphology and Glucose Transporter Gene Expression under a Chronic Intake of High Sucrose.Nutrients · 2024Article
- Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease.International journal of molecular sciences · 2022Article
- Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK.iScience · 2021Article
- Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.Molecular metabolism · 2021Review
- Absence of GIP secretion alleviates age-related obesity and insulin resistance.The Journal of endocrinology · 2020Article
- Physiological roles of the GIP receptor in murine brown adipose tissue.Molecular metabolism · 2019Article
- Diet-Induced Obese Mice and Leptin-DeficientInternational journal of molecular sciences · 2019Article
- The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review.International journal of molecular sciences · 2019Review
- Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice.Journal of diabetes investigation · 2019Article
- Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob/ob mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGlucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. GIP receptor knockout mice are protected from diet induced weight gain and thus GIP antagonists have been proposed as a treatment for obesity. In this study, we assessed the role of GIP in hyperphagia induced obesity and metabolic abnormalities in leptin deficient (Lep
methodsWe crossbred GIP-GFP knock-in homozygous mice (GIP
resultsPostprandial GIP levels were markedly elevated in Lep
conclusionsOur results indicate that GIP knockout does not prevent excess weight gain and metabolic derangement in hyperphagic leptin deficient mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.