Evidence map›Paper›PMID 28271016›Full record

ArticleBiomedical optics express2017

X-ray phase microtomography with a single grating for high-throughput investigations of biological tissue.

Marie-Christine Zdora, Joan Vila-Comamala, Georg Schulz, Anna Khimchenko, Alexander Hipp, Andrew C Cook, Daniel Dilg, Christian David, Christian Grünzweig, Christoph Rau and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Edge-illumination x-ray phase-contrast imaging.Journal of physics. Condensed matter : an Institute of Physics journal · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Marie-Christine ZdoraDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK; Department of Physics & Astronomy, University College London, London WC1E 6BT, UK.
Joan Vila-ComamalaInstitute for Biomedical Engineering, ETH Zürich, 8092 Zürich, Switzerland.
Georg SchulzBiomaterials Science Center, Department of Biomedical Engineering, University of Basel, 4123 Allschwil, Switzerland.
Anna KhimchenkoBiomaterials Science Center, Department of Biomedical Engineering, University of Basel, 4123 Allschwil, Switzerland.
Alexander HippHelmholtz-Zentrum Geesthacht, 21502 Geesthacht, Germany.
Andrew C CookUniversity College London Institute of Cardiovascular Science, London WC1E 6BT, UK.
Daniel DilgUniversity College London Institute of Cardiovascular Science, London WC1E 6BT, UK.
Christian DavidPaul Scherrer Institut, 5232 Villigen PSI, Switzerland.
Christian GrünzweigPaul Scherrer Institut, 5232 Villigen PSI, Switzerland.
Christoph RauDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK; School of Materials, University of Manchester, Manchester M1 7HS, UK; Department of Otolaryngology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Pierre ThibaultDepartment of Physics & Astronomy, University of Southampton, Southampton SO17 1BJ, UK.
Irene ZanetteDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK.
University College London · GBPaul Scherrer Institute · CHUniversity of Basel · CHDiamond Light Source · GBETH Zurich · CHHelmholtz-Zentrum Hereon · DENorthwestern University · USUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high-throughput 3D visualisation of biological specimens is essential for studying diseases and developmental disorders. It requires imaging methods that deliver high-contrast, high-resolution volumetric information at short sample preparation and acquisition times. Here we show that X-ray phase-contrast tomography using a single grating can provide a powerful alternative to commonly employed techniques, such as high-resolution episcopic microscopy (HREM). We present the phase tomography of a mouse embryo in paraffin obtained with an X-ray single-grating interferometer at I13-2 Beamline at Diamond Light Source and discuss the results in comparison with HREM measurements. The excellent contrast and quantitative density information achieved non-destructively and without staining using a simple, robust setup make X-ray single-grating interferometry an optimum candidate for high-throughput imaging of biological specimens as an alternative for existing methods like HREM.

Indexed as

(110.7440) X-ray imaging(170.3880) Medical and biological imaging(170.6960) Tomography(180.7460) X-ray microscopy(340.7450) X-ray interferometry

Identifiers

PMID28271016
PMCPMC5330582
OpenAlexW2584405977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.