ArticleBiomedical optics express2017
Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Article
- Spreading depolarization suppression from inter-astrocytic gap junction blockade assessed with multimodal imaging and a novel wavefront detection scheme.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Visualization of blood-brain barrier disruption with dual-wavelength high-resolution photoacoustic microscopy.Biomedical optics express · 2022Article
- A miniature multi-contrast microscope for functional imaging in freely behaving animals.Nature communications · 2019Article
- Data compression and improved registration for laser speckle contrast imaging of rodent brains.Biomedical optics express · 2018Article
- Decoding cortical brain states from widefield calcium imaging data using visibility graph.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We developed a multi-modal brain imaging system to investigate the relationship between blood flow, blood oxygenation/volume, intracellular calcium and electrographic activity during acute seizure-like events (SLEs), both before and after pharmacological intervention. Rising blood volume was highly specific to SLE-onset whereas blood flow was more correlated with all eletrographic activity. Intracellular calcium spiked between SLEs and at SLE-onset with oscillation during SLEs. Modified neurovascular and ionic SLE responses were observed after intervention and the interval between SLEs became shorter and more inconsistent. Comparison of artery and vein pulsatile flow suggest proximal interference and greater vascular leakage prior to intervention.
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Registered trials
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