ArticleBiomedical optics express2017
LIF spectroscopy of stained malignant breast tissues.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Fluorescence properties of methylene blue conjugated to normal/cancerous human tissues for spectral discrimination of breast cancer stages (I-IV).Biomedical optics express · 2026Article
- Nanocarrier-Assisted Laser-Driven Photodynamic/Chemo Therapy for Breast Cancer: A Narrative Review.Journal of lasers in medical sciences · 2026Review
- PC12 differentiation to neuron cells activated by a low-level laser at 660 nm on UV pre-treated CR-39 scaffolds with parallel microchannels.Biomedical optics express · 2024Article
- Discrimination of normal and cancerous human skin tissues based on laser-induced spectral shift fluorescence microscopy.Scientific reports · 2022Article
- Hybrid laser activated phycocyanin/capecitabine treatment of cancerous MCF7 cells.Biomedical optics express · 2022Article
- Optical characterization of the liver tissue affected by fibrolamellar hepatocellular carcinoma based on internal filters of laser-induced fluorescence.Scientific reports · 2022Article
- Spectroscopic Characteristics of Xeloda Chemodrug.Journal of lasers in medical sciences · 2021Article
- Cancerous Tissue Diagnosis by LIF Spectroscopy Derived From Body-Compatible Fluorophores.Journal of lasers in medical sciences · 2021Article
- Spectroscopic properties of various blood antigens/antibodies.Biomedical optics express · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We employ laser induced fluorescence (LIF) spectroscopy to discriminate between normal and cancerous human breast (in-vitro) tissues. LIF signals are usually enhanced by the exogenous agents such as Rhodamine 6G (Rd6G) and Coumarin 7 (C7). Although we observe fluorescence emissions in both fluorophores, Rd6G-stained tissues give notable spectral red shift in practice. The latter is a function of dye concentration embedded in tissues. We find that such red shifts have a strong dependence on the dye concentration in bare, in stained healthy, and in malignant breast tissues, signifying variations in tubular abundances. In fact, the heterogeneity of cancerous tissues is more prominent mainly due to their notable tubular densities- which can provide numerous micro-cavities to house more dye molecules. We show that this can be used to discriminate between the healthy and unhealthy specimens in different biological scaffolds of ordered (healthy) and disordered (cancerous) tissues. It is demonstrated that the quenching process of fluorophore' molecules slows down in the neoplastic tumors according to the micro-partitioning, too.
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