Evidence map›Paper›PMID 28270916›Full record

ArticleCanadian journal of kidney health and disease2016

Knowledge Translation Interventions to Improve the Timing of Dialysis Initiation: Protocol for a Cluster Randomized Trial.

Elaine M T Chau, Braden J Manns, Amit X Garg, Manish M Sood, S Joseph Kim, David Naimark, Gihad E Nesrallah, Steven D Soroka, Monica Beaulieu, Stephanie Dixon and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02183987 (Knowledge Translation Interventions to Prevent the Early Initiation of Dialysis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02183987 nacompletednot on this map

Knowledge Translation Interventions to Prevent the Early Initiation of Dialysis: A Cluster Randomized Trial

TypeinterventionalSponsorUniversity of ManitobaRan2014 to 2016Enrolled55ConditionsChronic Kidney DiseaseArmsActive Knowledge Translation Intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Multifaceted Intervention to Increase the Use of Home Dialysis: A Cluster Randomized Controlled Trial.Clinical journal of the American Society of Nephrology : CJASN · 2022
    Trial
  2. Trial
  3. Observational
  4. Article
  5. Infectious Disease Risk in Dialysis Patients: A Transdisciplinary Approach.Canadian journal of kidney health and disease · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 1 country.

Elaine M T ChauChronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba, Canada; Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Braden J MannsDepartment of Medicine, University of Calgary, Alberta, Canada.
Amit X GargDivision of Nephrology, Department of Medicine, Western University, London, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Manish M SoodThe Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.
S Joseph KimInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Department of Medicine, Division of Nephrology, University of Toronto, Ontario, Canada.
David NaimarkDivision of Nephrology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.
Gihad E NesrallahLi Ka Shing Knowledge Institute, Keenan Research Centre, St Michael's Hospital, and Nephrology Program, Humber River Hospital, Toronto, Ontario, Canada.
Steven D SorokaDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Monica BeaulieuDivision of Nephrology, University of British Columbia, Vancouver, Canada.
Stephanie DixonInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Ahsan AlamDivision of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada.
Navdeep TangriChronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba, Canada; Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Canadian Kidney Knowledge Translation and Generation Network (CANN-NET)
Dalhousie University · CAInstitute for Clinical Evaluative Sciences · CAMcGill University Health Centre · CASeven Oaks General Hospital · CASt. Michael's Hospital · CASunnybrook Health Science Centre · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Ottawa · CAUniversity of Toronto · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly initiation of chronic dialysis (starting dialysis with higher vs lower kidney function) has risen rapidly in the past 2 decades in Canada and internationally, despite absence of established health benefits and higher costs. In 2014, a Canadian guideline on the timing of dialysis initiation, recommending an intent-to-defer approach, was published.

objectiveThe objective of this study is to evaluate the efficacy and safety of a knowledge translation intervention to promote the intent-to-defer approach in clinical practice.

designThis study is a multicenter, 2-arm parallel, cluster randomized trial.

settingThe study involves 55 advanced chronic kidney disease clinics across Canada. PATIENTS: Patients older than 18 years who are managed by nephrologists for more than 3 months, and initiate dialysis in the follow-up period are included in the study. MEASUREMENTS: Outcomes will be measured at the patient-level and enumerated within a cluster. Data on characteristics of each dialysis start will be determined by linkages with the Canadian Organ Replacement Register. Primary outcomes include the proportion of patients who start dialysis early with an estimated glomerular filtration rate greater than 10.5 mL/min/1.73 m

methodsWe randomized 55 multidisciplinary chronic disease clinics (clusters) in Canada to receive either an active knowledge translation intervention or no intervention for the uptake of the guideline on the timing of dialysis initiation. The active knowledge translation intervention consists of audit and feedback as well as patient- and provider-directed educational tools delivered at a comprehensive in-person medical detailing visit. Control clinics are only exposed to guideline release without active dissemination. We hypothesize that the clinics randomized to the intervention group will have a lower proportion of early dialysis starts. LIMITATIONS: Limitations include passive dissemination of the guideline through publication, and lead-time and survivor bias, which favors delayed dialysis initiation.

conclusionsIf successful, this active knowledge translation intervention will reduce early dialysis starts, lead to health and economic benefits, and provide a successful framework for evaluating and disseminating future guidelines.

trial registrationClinicalTrials.gov, NCT02183987.

Indexed as

chronic kidney diseasecluster randomized trialdialysisearly dialysisend-stage renal diseaseintent-to-deferknowledge translationrandomized controlled trial

Identifiers

PMID28270916
PMCPMC5332084
OpenAlexW2529657532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.