Evidence map›Paper›PMID 28270890›Full record

ArticleJournal of clinical medicine research2017

An Elevated HbA1c Level Is Associated With Short-Term Adverse Outcomes in Patients With Gastrointestinal Cancer and Type 2 Diabetes Mellitus.

Yingchun Huang, Huazhen Zheng, Peicong Chen, Jin Yang, Shaomin Lin, Tingting Liu, Shanwei Chen, Siqiang Lu, Junlian Chen, Wenpu Chen and 1 more

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Article in Journal of clinical medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yingchun HuangDepartment of General Surgery, Jinling Hospital, Nanjing, Jiangsu Province, China; These authors contributed equally to this work.
Huazhen ZhengDepartment of Clinical Laboratory, The First People's Hospital of Foshan, Guangdong Province, China; These authors contributed equally to this work.
Peicong ChenFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China; These authors contributed equally to this work.
Jin YangFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Shaomin LinFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Tingting LiuFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Shanwei ChenFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Siqiang LuFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Junlian ChenFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Wenpu ChenFirst Clinical Medical College, Guangdong Medical University, Zhanjiang, Guangdong Province, China; Department of Endocrinology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China.
Nanhai PengDepartment of General Surgery, Jinling Hospital, Nanjing, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough an elevated hemoglobin A1c (HbAc1) level is an independent predictor of worse survival in patients with both digestive cancer and diabetes mellitus, its relationship to short-term prognosis in these patients has not been addressed. This study assessed this relationship in gastrointestinal cancer (GIC) patients with type 2 diabetes mellitus (T2DM).

methodsA retrospective review of patients with GIC with or without T2DM from 2004 to 2014 was performed. Patients with T2DM were grouped according to HbA1c level, either normal (mean < 7.0%) or elevated (mean ≥ 7.0%). Age- and sex-matched GIC patients without T2DM served as controls.

resultsOne hundred and eighteen patients aged 33 - 81 years with T2DM met the study eligibility criteria; 51 were in the normal HbA1c group, and 67 were in the elevated HbA1c group. The 91 patients in the non-T2DM group were randomly selected and matched to the T2DM group in terms of admittance date, age, and sex. There was a trend toward a higher 180-day mortality rate in the T2DM group compared with the non-T2DM group (15.3% vs. 7.7%, P = 0.095) and in the elevated HbA1c group compared with the normal HbA1c group (19.4% vs. 9.8%, P = 0.151); however, the differences were not significant. The duration of the hospital stay was longer in patients with T2DM than in those without T2DM (13.2 vs. 8.9 days, P < 0.05) and in patients with elevated versus normal HbA1c levels (14.5 vs. 11.4 days, P < 0.05). Diabetic GIC patients with elevated HbA1c levels had significantly more total postoperative complications than those with normal HbA1c levels (25.4% vs. 9.8%, P < 0.05). In multivariate regression analyses, short-term adverse outcomes were strongly associated with elevated HbA1c levels (odds ratio (OR): 5.276; 95% confidence level (CI): 1.73 - 16.095; P < 0.05) and no strict antidiabetic treatment (OR: 7.65; 95% CI: 2.49 - 23.54; P < 0.001).

conclusionAn elevated level of HbA1c significantly correlated with and was an independent predictor of short-term adverse outcomes in GIC patients with T2DM.

Indexed as

Gastrointestinal cancerHbA1cType 2 diabetes mellitus

Identifiers

PMID28270890
PMCPMC5330773

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.