ReviewFrontiers in neurology2017
Antagonistic and Synergistic Activation of Cardiovascular Vagal and Sympathetic Motor Outflows in Trigeminal Reflexes.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- A systematic review of HRV during diving in very cold water.International journal of circumpolar health · 2023Pooled it
- Applied forces with partially vs. fully inflated face masks during neonatal ventilation: a randomized crossover manikin trial.Pediatric research · 2026Trial
- Applied forces with high vs. low resuscitation table during neonatal ventilation: a randomized crossover manikin study.European journal of pediatrics · 2024Trial
- Effects of non-invasive trigeminal nerve stimulation frequency and duration on cardiovascular responses.Biomedical engineering letters · 2026Article
- Exploring the trigeminocardiac reflex: an integrated view from mechanism to clinic.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Effects of Adding Facial Immersion to Chest-Level Water Immersion on Vagally-Mediated Heart Rate Variability.Sports (Basel, Switzerland) · 2025Article
- Stimulus conditions eliciting sneezing in response to bright light.Experimental brain research · 2025Review
- Cold-induced stress responses during a self-rescue exercise from accidental immersion in ice water in military personnel.Frontiers in physiology · 2025Article
- Cluster Headache and Hypoxia: Breathing New Life into an Old Theory, with Novel Implications.Neurology international · 2024Review
- Cardiovascular Reflexes - Vagus as the Key Player.Current cardiology reviews · 2024Review
- Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach.Frontiers in neuroscience · 2024Article
- The Focus and New Progress of Percutaneous Balloon Compression for the Treatment of Trigeminal Neuralgia.Journal of pain research · 2022Review
- Prophylactic Intra-Arterial Injection of Lidocaine Prevents Trigeminocardiac Reflex During Endovascular Embolization for Dural Arteriovenous Fistula: A Report of 2 Cases.The American journal of case reports · 2021Article
- The Oculocardiac Reflex: A Review.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Effect of Apnea-Induced Hypoxia on Cardiovascular Adaptation and Circulating Biomarkers of Oxidative Stress in Elite Breath-Hold Divers.Frontiers in physiology · 2021Article
- Neuromodulation as a new avenue for resuscitation in hemorrhagic shock.Bioelectronic medicine · 2019Review
- Diving in the Arctic: Cold Water Immersion's Effects on Heart Rate Variability in Navy Divers.Frontiers in physiology · 2019Article
- Barometric pressure change and heart rate response during sleeping at ~ 3000 m altitude.International journal of biometeorology · 2018Article
- The association between surgical technique and oculocardiac reflex in pediatric strabismus surgery: an observational study.Brazilian journal of anesthesiology (Elsevier)Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The trigeminal nerve and heart are strongly related through somato-autonomic nervous reflexes that induce rapid changes in cardiovascular function. Several trigeminal reflexes have been described, but the diving and trigeminocardiac reflexes are the most studied. The heart is a target organ dually innervated by the sympathetic and parasympathetic systems. Thus, how cardiac function is regulated during the trigeminal reflexes is the result of the combination of an increased parasympathetic response and increased, decreased, or unaltered sympathetic activity. Various hemodynamic changes occur as a consequence of these alterations in autonomic tone. Often in the oxygen-conserving physiological reflexes such as the diving reflex, sympathetic/parasympathetic co-activation reduces the heart rate and either maintains or increases blood pressure. Conversely, in the trigeminocardiac reflex, bradycardia and hypotension due to parasympathetic activation and sympathetic inactivation tend to be observed. These sudden cardiac innervation disturbances may promote the generation of arrhythmias or myocardial ischemia during surgeries in the trigeminal territory. However, the function and mechanisms involved in the trigeminal reflexes remain to be fully elucidated. The current review provides a brief update and analysis of the features of these reflexes, with special focus on how the autonomic nervous system interacts with cardiovascular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.