Evidence map›Paper›PMID 28270749›Full record

ArticleFrontiers in cellular neuroscience2017

Identifying Candidate Genes that Underlie Cellular pH Sensitivity in Serotonin Neurons Using Transcriptomics: A Potential Role for Kir5.1 Channels.

Madeleine M Puissant, Gary C Mouradian, Pengyuan Liu, Matthew R Hodges

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. Deletion ofFrontiers in cell and developmental biology · 2021
    Article
  8. Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019
    Review
  9. Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Madeleine M PuissantDepartment of Physiology, Medical College of Wisconsin, MilwaukeeWI, USA; Neuroscience Research Center, Medical College of Wisconsin, MilwaukeeWI, USA.
Gary C MouradianDepartment of Physiology, Medical College of Wisconsin, MilwaukeeWI, USA; Center for Systems Molecular Medicine, Medical College of Wisconsin, MilwaukeeWI, USA.
Pengyuan LiuDepartment of Physiology, Medical College of Wisconsin, MilwaukeeWI, USA; Center for Systems Molecular Medicine, Medical College of Wisconsin, MilwaukeeWI, USA; Cancer Research Center, Medical College of Wisconsin, MilwaukeeWI, USA.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, MilwaukeeWI, USA; Neuroscience Research Center, Medical College of Wisconsin, MilwaukeeWI, USA; Center for Systems Molecular Medicine, Medical College of Wisconsin, MilwaukeeWI, USA.
Medical College of Wisconsin · USCancer Research Center · US

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Roles of peripheral and central respiratory chemoreceptors in inbred rat strainsR00HL097033 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2011 to 2013
$718k
Roles of peripheral and central respiratory chemoreceptors in inbred rat strainsK99HL097033 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2009 to 2010
$180k
NHLBI NIH HHS K99 HL097033NHLBI NIH HHS R00 HL097033NHLBI NIH HHS R01 HL122358NHLBI NIH HHS T32 HL007852
6 · The paper itself

Abstract

Ventilation is continuously adjusted by a neural network to maintain blood gases and pH. Acute CO

Indexed as

chemoreceptioncontrol of breathingpotassium channelsRNA sequencingserotonin

Identifiers

PMID28270749
PMCPMC5318415
OpenAlexW2591110817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.