ArticleThe Journal of antibiotics2017
OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum.
Article in The Journal of antibiotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Regulatory and metabolic control of microbial biosynthetic gene clusters.Communications biology · 2026Review
- Metabolite diversification via halogen salts enhances biocontrol potential of marine-derived Trichoderma virens B211.Natural products and bioprospecting · 2026Article
- GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits.Natural products and bioprospecting · 2026Article
- Nematicidal indole oxazoles and chemoattractants from soil bacteria.bioRxiv : the preprint server for biology · 2026Article
- Anticancer Secondary Metabolites Produced by Fungi: Potential and Representative Compounds.International journal of molecular sciences · 2025Review
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- Discovery of thiazostatin D/E using UPLC-HR-MS2-based metabolomics and σ-factor engineering ofFrontiers in bioengineering and biotechnology · 2024Article
- The endophyticRSC advances · 2023Review
- Review
- Transcriptome Analysis Reveals the Putative Polyketide Synthase Gene Involved in Hispidin Biosynthesis inMycobiology · 2023Article
- Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents.Marine drugs · 2022Review
- Distribution, pathogenicity and disease control ofFrontiers in microbiology · 2022Review
- OSMAC Strategy Integrated with Molecular Networking for Accessing Griseofulvin Derivatives from Endophytic Fungi ofMolecules (Basel, Switzerland) · 2021Article
- New Acetophenones and Chromenes from the Leaves ofMolecules (Basel, Switzerland) · 2021Article
- Fungal endophytes in Peperomia obtusifolia and their potential as inhibitors of chickpea fungal pathogens.World journal of microbiology & biotechnology · 2021Article
- Endophytic fungi: A treasure trove of novel anticancer compounds.Current research in pharmacology and drug discovery · 2021Article
- Screening of Fungi for Antimycobacterial Activity Using a Medium-Throughput Bioluminescence-Based Assay.Frontiers in microbiology · 2021Article
- Review
- Bioprospecting endophytic fungi fromMycology · 2020Review
- Secondary metabolites from theBMC chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the OSMAC (One Strain MAny Compounds) approach, the fungal endophyte Fusarium tricinctum was cultivated on fruit and vegetable juice-supplemented solid rice media. This led to an up to 80-fold increase in the accumulation of the new natural product fusarielin J (1), as well as to the induction of two new natural products fusarielin K (2) and fusarielin L (3) and the known derivatives fusarielins A (4) and B (5). Compounds 2-5 were not detected when the fungus was grown on rice media lacking either fruit or vegetable juice. The highest increase in the accumulation of compound 1 was observed in the presence of apple and carrot juice, whereas the stimulating effect was weaker for banana juice. Compound 1 exhibited cytotoxicity against the human ovarian cancer cell line A2780, with an IC
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