ArticlemBio2017
Microevolution of Serial Clinical Isolates of
Open access · goldAbstract read
In one paragraph
Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 86 citations in OpenAlex.
- Immune Modulation and Evasion byACS omega · 2026Review
- Mammalian-evolved strains of the fungal pathogen Cryptococcus neoformans show adaptation via heritable transcript level differences specific to mouse MHC haplotype.BMC genomics · 2026Article
- Extending Trait-Based Ecology Across Disciplines in the Face of Global Change.Ecology and evolution · 2026Review
- Temperature and genetic background drive mobilization of diverse transposable elements in a global human fungal pathogen.PLoS genetics · 2026Article
- Intrinsic and extrinsic factors affecting the evolution of virulence in the HIV-associated opportunistic human fungal pathogenVirulence · 2025Article
- Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective.Virulence · 2025Review
- Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts.Cell reports · 2025Article
- Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait.PLoS pathogens · 2025Article
- Cryptococcal nutrient acquisition and pathogenesis: dining on the host.Microbiology and molecular biology reviews : MMBR · 2025Review
- Microevolution of Cryptococcus neoformans in high COCell reports · 2025Article
- The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024Review
- Genetic diversity and microevolution in clinical Cryptococcus isolates from Cameroon.Medical mycology · 2023Article
- Unbiased discovery of natural sequence variants that influence fungal virulence.Cell host & microbe · 2023Article
- Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity.Current biology : CB · 2023Article
- Impact of pathogen genetics on clinical phenotypes in a population of Talaromyces marneffei from Vietnam.Genetics · 2023Article
- Impact of pathogen genetics on clinical phenotypes in a population ofbioRxiv : the preprint server for biology · 2023Article
- Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Landscape of the Genomic Structure ofJournal of fungi (Basel, Switzerland) · 2023Article
- Similar evolutionary trajectories in an environmentalProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Yuan ChenDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-7652-153X
Rhys A FarrerBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
Charles GiamberardinoDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Sharadha SakthikumarBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
Alexander JonesDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Timothy YangDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Jennifer L TenorDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Omar WagihEuropean Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
Marelize Van WykNational Institute for Communicable Diseases (Centre for Opportunistic, Tropical, and Hospital Infections), A Division of the National Health Laboratory Service, Johannesburg, South Africa.
Nelesh P GovenderNational Institute for Communicable Diseases (Centre for Opportunistic, Tropical, and Hospital Infections), A Division of the National Health Laboratory Service, Johannesburg, South Africa.
Thomas G MitchellDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Anastasia P LitvintsevaMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Christina A CuomoBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA cuomo@broadinstitute.org john.perfect@dm.duke.edu.ORCID 0000-0002-5778-960X
John R PerfectDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA cuomo@broadinstitute.org john.perfect@dm.duke.edu.
Duke Medical Center · USBroad Institute · USDuke University · USNational Health Laboratory Service · ZACenters for Disease Control and Prevention · USEuropean Bioinformatics Institute · GB
Funding
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI CUOMO, CHRISTINA A · 2014 to 2024
$66.5MPathobiology of C. neoformans in the Central Nervous SystemR01AI073896 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2008 to 2018
$4.4MEvolution of Cryptococcus neoformans Strains from Patients with HIV/AIDSR01AI093257 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2011 to 2022
$3.8MSTUDIES OF CRYPTOCOCCUS NEOFORMANTS ASSOCIATED WITH AIDSR01AI025783 · NIAID · DUKE UNIVERSITY · PI MITCHELL, THOMAS G. · 1987 to 2010
$2.1MNIAID NIH HHS R01 AI025783NIAID NIH HHS R01 AI073896NIAID NIH HHS R01 AI093257NIAID NIH HHS U19 AI110818Wellcome Trust
Abstract
The pathogenic species of
Indexed as
Adaptation, BiologicalEvolution, MolecularCerebrospinal FluidCryptococcus gattiiCryptococcus neoformansDrug Resistance, FungalGenotypeHumansLongitudinal StudiesMeningitis, CryptococcalPhenotypeRecurrenceSouth AfricaTemperatureVirulence
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.