ArticleBlood2017
Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.
Open access · bronzeAbstract read
In one paragraph
Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Loss of lactate dehydrogenase A disrupts R-loop homeostasis and induces DNA damage in breast cancer cells.Frontiers in genetics · 2026Article
- Decoding nucleoside supplementation: how thymidine outperforms ribonucleosides in accelerating mammalian replication forks.Nucleic acids research · 2025Article
- DNA-dependent phase separation by human SSB2 (NABP1/OBFC2A) protein points to adaptations to eukaryotic genome repair processes.Protein science : a publication of the Protein Society · 2024Article
- The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair.Frontiers in pharmacology · 2024Article
- Article
- Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34Haematologica · 2022Article
- Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection.The Journal of experimental medicine · 2021Review
- High-resolution, ultrasensitive and quantitative DNA double-strand break labeling in eukaryotic cells using i-BLESS.Nature protocols · 2021Article
- Genome-wide detection of DNA double-strand breaks by in-suspension BLISS.Nature protocols · 2020Article
- FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.Nucleic acids research · 2020Article
- SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- A Structural Perspective on the Regulation of Human Single-Stranded DNA Binding Protein 1 (hSSB1, OBFC2B) Function in DNA Repair.Computational and structural biotechnology journal · 2019Review
- The role of telomere binding molecules for normal and abnormal hematopoiesis.International journal of hematology · 2018Review
- Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.Scientific reports · 2018Article
- Review
- The importance of tying up loose (DNA) ends.Blood · 2017Article
Corrections and comments
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Authors and funding
28 authors at 10 institutions in 4 countries.
Wei ShiQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Therese VuQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Didier BoucherQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Anna BiernackaLaboratory of Bioinformatics and Systems Biology, Center of New Technologies, University of Warsaw, Warsaw, Poland.
Jules NdeDepartment of Biochemistry & Molecular Biology, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX.
Raj K PanditaDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX.
Jasmin StraubeQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Glen M BoyleQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Fares Al-EjehQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Purba NagQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0002-6863-5438
Jessie JefferyQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Janelle L HarrisQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Amanda L BainQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Marta GrzelakLaboratory of Bioinformatics and Systems Biology, Center of New Technologies, University of Warsaw, Warsaw, Poland.
Magdalena SkrzypczakLaboratory of Bioinformatics and Systems Biology, Center of New Technologies, University of Warsaw, Warsaw, Poland.
Abhishek MitraDepartment of Biochemistry & Molecular Biology, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX.
Norbert DojerDepartment of Biochemistry & Molecular Biology, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX.
Nicola CrosettoScience for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Nicole CloonanQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Olivier J BecherelSchool of Medicine, University of Queensland, Brisbane, QLD, Australia.
John FinnieSouth Australia Pathology and School of Veterinary Science, University of Adelaide, Adelaide, SA, Australia.
Jeffrey R SkaarDepartment of Pathology, Cancer Institute, New York University School of Medicine, New York, NY.
Carl R WalkleySt. Vincent's Institute of Medical Research and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, VIC, Australia; and.
Tej K PanditaDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX.
Maga RowickaDepartment of Biochemistry & Molecular Biology, Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX.
Krzysztof GinalskiLaboratory of Bioinformatics and Systems Biology, Center of New Technologies, University of Warsaw, Warsaw, Poland.
Steven W LaneQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0002-8050-6209
Kum Kum KhannaQIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID 0000-0001-8650-5381
QIMR Berghofer Medical Research Institute · AUThe University of Texas Medical Branch at Galveston · USUniversity of Warsaw · PLThe University of Queensland · AUHouston Methodist · USGriffith University · AUNew York University · USScience for Life Laboratory · SESouth Australia Pathology · AUSt Vincent's Hospital Melbourne · AU
Funding
CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITYR01CA129537 · NCI · WASHINGTON UNIVERSITY · PI PANDITA, TEJ K · 2008 to 2018
$3.3MDecoding Genome Instability by Combining Accurate Mapping and Predictive ModelingR01GM112131 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ROWICKA, MAGA MALGORZATA · 2014 to 2023
$3.2MTumor-cell-specific targets for combined hyperthermia and radiation effectsR01CA154320 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI PANDITA, TEJ K · 2010 to 2014
$1.6MRole of Heterochromatin protein 1 Beta in Genome Maintenance and OncogenesisR01GM109768 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI PANDITA, TEJ K · 2014 to 2017
$1.2MNCI NIH HHS R01 CA129537NCI NIH HHS R01 CA154320NIGMS NIH HHS R01 GM109768NIGMS NIH HHS R01 GM112131
Abstract
Hematopoietic stem and progenitor cells (HSPCs) are vulnerable to endogenous damage and defects in DNA repair can limit their function. The 2 single-stranded DNA (ssDNA) binding proteins SSB1 and SSB2 are crucial regulators of the DNA damage response; however, their overlapping roles during normal physiology are incompletely understood. We generated mice in which both
Indexed as
DNA Breaks, Double-StrandedAnimalsCell ProliferationCell SurvivalCpG IslandsGenomic InstabilityHematopoietic Stem CellsMiceMice, KnockoutSuppressor of Cytokine Signaling ProteinsTumor Suppressor Protein p53SSB-1 protein, mouseSSB-4 protein, mouseSuppressor of Cytokine Signaling ProteinsTumor Suppressor Protein p53
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.