Evidence map›Paper›PMID 28270216›Full record

Trial reportItalian journal of pediatrics2017

Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma.

Michele Miraglia Del Giudice, Cristiana Indolfi, Michele Capasso, Nunzia Maiello, Fabio Decimo, Giorgio Ciprandi

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Italian journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02807064 (Evaluation of the Effectiveness of Treatment With Bifidobacteria in Children Affected by Seasonal Allergic Rhinitis), which is not on this map. Cited by 70 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 9 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02807064 phase3unknown statusnot on this map

Evaluation of the Effectiveness of Treatment With Bifidobacteria in Children Affected by Seasonal Allergic Rhinitis

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2016 to 2019Enrolled40ConditionsSeasonal Allergic RhinitisArmsBifidobacteria, placebo
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 9 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Frontiers in nutrition · 2026
    Trial
  11. Efficacy ofJournal of Korean medical science · 2024
    Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Efficacy ofNutrients · 2018
    Trial
  17. Review
  18. Exploring the Adhesion Potential ofFoods (Basel, Switzerland) · 2026
    Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michele Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
Cristiana IndolfiDepartment of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
Michele CapassoDepartment of Paediatrics, Ospedale Civile 'Ave Gratia Plena', Piedimonte Matese, CE, Italy.
Nunzia MaielloDepartment of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
Fabio DecimoDepartment of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
Giorgio CiprandiDepartment of Medicine, IRCCS-AOU San Martino-IST, Genoa, Italy. gio.cip@libero.it.
University of Campania "Luigi Vanvitelli" · ITUniversity of Naples Federico II · ITOspedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAllergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction. Probiotics may exert anti-inflammatory and immune-modulatory activity. Thus, this study aimed at investigating whether a Bifidobacteria mixture could be able to relieve nasal symptoms, and affect quality of life (QoL) in children with AR and intermittent asthma due to Parietaria allergy. MATERIALS AND

methodsThe present study was conducted as placebo-controlled, double-blinded, and randomized. Globally, 40 children (18 males; mean age 9 ± 2.2 years) were enrolled. They were treated with probiotics or placebo: 1 sachet/day for 4 weeks. AR symptoms, and QoL were assessed at baseline and after treatment. Use of rescue medications, such as cetirizine syrup and salbutamol spray, was also permitted and recorded.

resultsChildren treated with probiotic mixture achieved a significant improvement of symptoms (p < 0.005), and QoL ((p < 0.001). Placebo group had worsening of symptoms (p < 0.005) and QoL (p < 0.001). The use of rescue medications was overlapping in the two groups. The intergroup analysis showed that probiotic mixture was significantly superior than placebo for all parameters.

conclusionsThe current study demonstrated that a Bifidobacteria mixture was able of significantly improving AR symptoms and QoL in children with pollen-induced AR and intermittent asthma. CLINICAL

trial registrationClinicalTrials.gov ID NCT02807064 .

Indexed as

BifidobacteriumAdministration, OralAdolescentAsthmaChildChild, PreschoolDose-Response Relationship, DrugDouble-Blind MethodDrug CombinationsFemaleFollow-Up StudiesHumansMaleProbioticsProspective StudiesQuality of LifeDrug CombinationsAllergic rhinitisBifidobacteriaChildrenIntermittent asthmaProbioticQuality of life

Identifiers

PMID28270216
PMCPMC5341466
OpenAlexW2592714863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.