Observational studyItalian journal of pediatrics2017
Sedation and analgesia practices at Italian neonatal intensive care units: results from the EUROPAIN study.
Observational study in Italian journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
European Survey of Sedation and Analgesia Practices for Newborns Admitted to Intensive Care Units
Use of Oral 40% Destrogel to Prevent Hypoglycaemia in Late-term Births and SGA or LGA Term Newborns
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Opioids for newborn infants receiving mechanical ventilation.The Cochrane database of systematic reviews · 2021Pooled it
- Tipping the scale to no pain: Knowledge synthesis of procedural pain management in neonates.Paediatrics & child health · 2025Article
- Pain management for placement of peripherally inserted central catheters in neonates: A systematic review and meta-analysis.Paediatrics & child health · 2025Article
- Intranasal Fentanyl in Preterm Infants Undergoing Peripherally Inserted Central Catheter Placement (INFENT PICC): A Feasibility Randomized Controlled Trial.Children (Basel, Switzerland) · 2025Article
- A nomogram to predict extubation failure in infants born before 32 gestational weeks: a single-center retrospective study.Translational pediatrics · 2025Article
- Intranasal Analgesia in Preterm and Term Neonates.Paediatric drugs · 2025Review
- Current practices in neonatal pain management: a decade after the last Italian survey.Italian journal of pediatrics · 2025Article
- Retrospective analysis of the analgosedative efficacy and safety of midazolam combined with fentanyl in mechanically ventilated neonates.Frontiers in pediatrics · 2025Article
- Article
- Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants.Pediatric research · 2023Article
- Use of narcotics and sedatives among very preterm infants in neonatal intensive care units in China: an observational cohort study.Translational pediatrics · 2023Article
- Evidence-Based Nursing Practices for the Prevention of Newborn Procedural Pain in Neonatal Intensive Therapy-An Exploratory Study.International journal of environmental research and public health · 2022Article
- Usefulness of two types of pain monitors in newborns treated in NICU, in the opinion of experts: Results of the survey.Journal of mother and child · 2022Article
- Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Intranasal Fentanyl for Procedural Analgesia in Preterm Infants.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Newborn infant parasympathetic evaluation for the assessment of analgosedation adequacy in infants treated by mechanical ventilation - a multicenter pilot study.Archives of medical science : AMS · 2021Article
- Article
- A survey of procedural pain assessment and non-pharmacologic analgesic interventions in neonates in Spanish public maternity units.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Advances in pediatrics in 2017: current practices and challenges in allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, neurology, pulmonology from the perspective of Italian Journal of Pediatrics.Italian journal of pediatrics · 2018Review
- Respiratory Care for the Ventilated Neonate.Canadian respiratory journal · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to examine current bedside analgesia/sedation (A/S) and pain assessment (PA) practices in Italian neonatal intensive care units (NICUs) in relation to the findings of an epidemiological European study and recently-introduced national guidelines.
methodsWe analyzed the Italian data from the EUROPAIN (EUROpean-Pain-Audit-In-Neonates) prospective observational study on A/S practices that involved 6680 newborns admitted to tertiary-level NICUs in 18 European countries. Demographics, type of assisted ventilation, type and mode of A/S administration and PA were analyzed. Multivariate linear regression models were used to identify factors predicting A/S and PA practices.
resultsFrom October 1
conclusionsWe documented a generally widespread, but still highly variable use of A/S and PA at Italian NICUs, despite the diffusion of national guidelines. There is an urgent need to improve routine PA to enable customized pain and stress control (and prevention) in all infants.
trial registrationClinical Trials.gov # NCT01694745 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.