ArticleBMC evolutionary biology2017
Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Comparison of HIV-1 A6 dispersal dynamics in Poland before and after the war in Ukraine.PLoS pathogens · 2025Article
- Phylodynamics for Human Immunodeficiency Virus Prevention: A Miami-Dade County Case Study.The Journal of infectious diseases · 2025Article
- Phylodynamics of HIV in the Mexico City Metropolitan Region.Journal of virology · 2022Article
- Molecular Epidemiology and Baseline Resistance of Hepatitis C Virus to Direct Acting Antivirals in Croatia.Pathogens (Basel, Switzerland) · 2022Article
- Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico.Viruses · 2022Article
- Dynamics and Dispersal of Local Human Immunodeficiency Virus Epidemics Within San Diego and Across the San Diego-Tijuana Border.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Comparative Circulation Dynamics of the Five Main HIV Types in China.Journal of virology · 2020Article
- Pretreatment HIV drug resistance spread within transmission clusters in Mexico City.The Journal of antimicrobial chemotherapy · 2020Article
- Article
- Evolutionary dynamics and transmission patterns of Newcastle disease virus in China through Bayesian phylogeographical analysis.PloS one · 2020Article
- Discussion on critical points for a tailored therapy to cure hepatitis C virus infection.Clinical and molecular hepatology · 2019Review
- Increasing importance of European lineages in seeding the hepatitis C virus subtype 1a epidemic in Spain.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- On the importance of negative controls in viral landscape phylogeography.Virus evolution · 2018Article
- The global origins of resistance-associated variants in the non-structural proteins 5A and 5B of the hepatitis C virus.Virus evolution · 2018Article
- Accurate quantification of within- and between-host HBV evolutionary rates requires explicit transmission chain modelling.Virus evolution · 2017Article
- Cross-border spread, lineage displacement and evolutionary rate estimation of rabies virus in Yunnan Province, China.Virology journal · 2017Article
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17 authors.
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Abstract
backgroundIn-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data.
resultsOur results showed that both immigration and local circulation fuel the current Italian HCV1a epidemic. The United States and European continental lineages dominate import into Italy, with the latter taking the lead from the 1970s onwards. Since similar migration patterns were found for Q80K and other lineages, no clear differentiation of the risk for failing simeprevir can be made between patients based on their migration and travel history. Importantly, since HCV only occasionally recombines, these results are readily transferable to the genetic sequencing policy concerning NS5A RAVs.
conclusionsThe patient migration and travel history cannot be used to target only part of the HCV1a infected population for drug resistance testing before start of antiviral therapy. Consequently, it may be cost-effective to expand genotyping efforts to all HCV1a infected patients eligible for simeprevir-based therapies.
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