Evidence map›Paper›PMID 28268096›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2017

Impact of long-lasting insecticidal nets on prevalence of subclinical malaria among children in the presence of pyrethroid resistance in Anopheles culicifacies in Central India.

Mehul Kumar Chourasia, Raghavendra Kamaraju, Immo Kleinschmidt, Rajendra M Bhatt, Dipak Kumar Swain, Tessa Bellamy Knox, Neena Valecha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mehul Kumar ChourasiaNational Institute of Malaria Research (ICMR) IIR-WHO Project, Field Unit, Kondagaon, Chhattisgarh, India. Electronic address: mehul4frnds@gmail.com.
Raghavendra KamarajuNational Institute of Malaria Research (ICMR), Sector-8, Dwarka, New Delhi 110077, India. Electronic address: kamarajur2000@yahoo.com.
Immo KleinschmidtDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: immo.kleinschmidt@lshtm.ac.uk.
Rajendra M BhattNational Institute of Malaria Research (ICMR), Field Unit, Lalpur, Raipur Chhattisgarh, India. Electronic address: rmbhatt@rediffmail.com.
Dipak Kumar SwainNational Institute of Malaria Research (ICMR) IIR-WHO Project, Field Unit, Kondagaon, Chhattisgarh, India. Electronic address: dipakswain@gmail.com.
Tessa Bellamy KnoxWorld Health Organization, Avenue Appia, 1211 Geneva-27, Switzerland. Electronic address: knoxt@who.int.
Neena ValechaNational Institute of Malaria Research (ICMR), Sector-8, Dwarka, New Delhi 110077, India. Electronic address: neenavalecha@gmail.com.
National Institute of Malaria Research · INLondon School of Hygiene & Tropical Medicine · GBWorld Health Organization · CH

Funding

Medical Research Council MR/K012126/1World Health Organization 001
6 · The paper itself

Abstract

backgroundSubclinical (asymptomatic) cases of malaria could be a major barrier to the success of malaria elimination programs. This study has evaluated the impact of long-lasting insecticidal nets (LLINs) on the prevalence of subclinical malaria in the presence of pyrethroid resistance in the main malaria vector Anopheles culicifacies on malaria transmission among a cohort of children in villages of the Keshkal sub-district in Chhattisgarh state.

methodsA cohort of 6582 children ages less than 14 years was enrolled from 80 study clusters. Post monsoon survey was carried out at baseline before LLIN distribution, and 5862 children were followed up in the subsequent year. Study outcomes included assessment of subclinical malarial infections and use of LLINs among the study cohort in the presence of varied levels of pyrethroid resistance.

findingsIn the baseline survey, the proportion of subclinical malaria was 6·1%. LLIN use during the previous night was 94·8%. Overall, prevalence of subclinical malaria was significantly reduced to 1% (p<0·001) in the second survey. LLIN users were protected from malaria (OR: 0·25, 95% CI=0·12-0·52, p<0.001) and subclinical malaria (OR: 0·25, 95% CI=0·11-0·58, p=0·001) despite the presence of pyrethroid resistance in the study area.

interpretationIn this low transmission area, sleeping under LLINs significantly reduced the burden of malaria among children. In the presence of pyrethroid resistant malaria vector, a high LLIN use of 94·5% was observed to have significantly brought down the proportion of subclinical malaria among the cohort children.

Indexed as

AnophelesInsecticide-Treated BednetsAnimalsChildFemaleHumansIndiaInfantInsecticide ResistanceInsecticidesMalariaMaleMosquito ControlPrevalencePyrethrinsInsecticidesPyrethrinsIndiaLLINMalariaPyrethroid resistanceSubclinical malaria

Identifiers

PMID28268096
PMCPMC5384434
OpenAlexW2592476726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.